DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP011963

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_552275.3	Gene:	AgaP_AGAP011963 / 3291462	VectorBaseID:	AGAP011963	Length:	983	Species:	Anopheles gambiae

Alignment Length:	769	Identity:	159/769 - (20%)
Similarity:	254/769 - (33%)	Gaps:	263/769 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VHSARGDQLEVTTIVNQH---------FPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSL 79
            |.:|..|.:||..:.|..         .|.::.|||     ||...:.|.    ....|.|.||.
Mosquito   133 VDTAHDDMMEVNGLSNLPEATKVQPVVLPAEVPKES-----GREGSVASG----DSGESCASSSS 188

  Fly    80 QETKVALMEDDPLTQETTSFPEIIKLATQEE---------EGVTE----------PQELGGR--- 122
            .|..|.:..:  :|:::|:.|  :.:.|.:|         |.|.|          |:...||
Mosquito   189 TEEAVGVAIE--VTKQSTAGP--VGVDTLKESSPASDSGIESVNESGTPAASSSVPKRPRGRPKS 249

  Fly   123 NFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLR---KRLKAEDGSSVDKDKDED 184
            ...:.....:|.:....|     :::...|:.|..|....:.|:   .|.|:...:|:..:| ||
Mosquito   250 TVSFAGASAKEDKPSQQP-----DQAKLQQQQQQPLVKEEKELKPRPARRKSIHNASLASEK-ED 308

  Fly   185 GV--EETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEE------------ 235
            |.  ||:|..|.|.:..|:     .||...:||      .:||:|..|..:.|
Mosquito   309 GAEEEESAVVATPARTAGK-----RAVRTARKP------SVKAKEAAESAEVEQQAAAEAVAVAV 362

  Fly   236 ----------------------------------TDP-DFSCLVPSDNSSEDDGGS--------- 256
                                              .:| :.:.|:.::.|||..|.|
Mosquito   363 ATSAGGEAGTKCSKCELCFKTELWYRKHLINVHGMEPEEVTRLLLAEGSSESKGSSPAVPEVAAA 427

  Fly   257 --------DGFDSD-----------------SDFELDNGKQE-----------FAVLPKRTVVRP 285
                    :|.|..                 :|..|.||..:           .||..|.....|
Mosquito   428 APEPAILTNGGDETTKQVSTVGETVEAAAAVADESLQNGHSDEVAQTTNLSPVAAVPSKLAQTSP 492

  Fly   286 KKYKKRT-----KPAEPKVRMSRELLEQRKKQQEEYDV--IIAKFFTSVLPCAICNLLVHNFTEM 343
            ...:||.     :..||.|..|.:.|......:....|  ::      |||.|         .::
Mosquito   493 STGRKRKSTPYHEEEEPSVPTSTDALAGSNNSEPALPVKELV------VLPPA---------AKV 542

  Fly   344 QRHHR----LTHQVD-PGYMMCCGRKFTQRK-----VLAEHVLVHWNPD---------------- 382
            :..||    .|.:.: |...:..|::..:|:     .:|........||
Mosquito   543 KVEHRAQKATTEETESPPTELAPGQQLAKRRKSSITPIATEATKQEKPDPDDPDKLTPFESAKVT 607

  Fly   383 ----------HFKCSVCEKSFQNSRHLESH-QQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLN 436
                      |:.|::|...|.....::.| ..||  .|:|.. ||:.|.:|||....:..| :.
Mosquito   608 VLESEMTGETHYTCTICGGQFTGKATIKEHLDTVH--AAIKRR-SCEYCGRTFLQTGDLTRH-VR 668

  Fly   437 KHVPKSEFKFTCSECNKKFLTERKLKNHM-----SSMHDPESTIICDKCGKQMRTKIILKKHQEL 496
            .|..:..||....||:..|::...|..|:     ..|..|.   :||:|||.......||:| :.
Mosquito   669 IHTGQRPFKCPVVECSFAFISSGDLHKHVRRHNQQPMPKPH---VCDQCGKDFERSYDLKRH-KT 729

  Fly   497 MHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHN 561
            ||:   :.||:          .||:|                  |.:|.||.......|.|.| .
Mosquito   730 MHA---KSEPD----------FKGIT------------------CGVCGKVFARRDQFRAHTY-R 762

  Fly   562 HECERKFKCTMCEKAFKRPQELKEHTSTHTGE-VLYTCPNCPMTFFCSANMYKH 614
            |...|.::|.:|.|:|..|....:|...|..: |...|..|...|...:.:.||
Mosquito   763 HIGYRPYQCEICGKSFTDPSNYSKHARLHEMDGVEVVCNFCNRPFKNKSAISKH 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	17/65 (26%)
		FYDLN_acid	<191..268	CDD:302856	22/157 (14%)
		C2H2 Zn finger	330..351	CDD:275368	3/24 (13%)
		C2H2 Zn finger	360..378	CDD:275368	3/22 (14%)
		LIM	361..>400	CDD:295319	9/69 (13%)
		C2H2 Zn finger	386..406	CDD:275368	4/20 (20%)
		zf-C2H2_8	389..465	CDD:292531	21/76 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	3/20 (15%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/17 (29%)
AgaP_AGAP011963	XP_552275.3	C2H2 Zn finger	711..731	CDD:275368	8/20 (40%)
		zf-C2H2	742..763	CDD:278523	8/39 (21%)
		C2H2 Zn finger	743..763	CDD:275368	7/20 (35%)
		zf-H2C2_2	756..779	CDD:290200	8/23 (35%)
		zf-C2H2	769..791	CDD:278523	6/21 (29%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		C2H2 Zn finger	800..817	CDD:275368	5/17 (29%)
		COG5048	<500..787	CDD:227381	74/341 (22%)
		C2H2 Zn finger	621..642	CDD:275368	4/20 (20%)
		C2H2 Zn finger	650..670	CDD:275368	6/20 (30%)
		zf-H2C2_2	662..689	CDD:290200	7/27 (26%)
		C2H2 Zn finger	678..700	CDD:275368	5/21 (24%)
		zf-C2H2	709..731	CDD:278523	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910