DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP002165

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_565666.4	Gene:	AgaP_AGAP002165 / 3290570	VectorBaseID:	AGAP002165	Length:	654	Species:	Anopheles gambiae

Alignment Length:	684	Identity:	134/684 - (19%)
Similarity:	219/684 - (32%)	Gaps:	200/684 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QHFPVQISKESDERICGRCW-----KIVSDFHTL---HEFVSAAQS----SLQETKVALMEDDPL 92
            |||            |.| |     .|.|.|..|   .:||....:    ||:..:|.      |
Mosquito     5 QHF------------CLR-WNNYQSSITSAFENLRDDEDFVDVTLACDGRSLKAHRVV------L 50

  Fly    93 TQETTSFPEIIKLATQEEEGVTEPQELGGRN-------FFYPEIKIEEHELDT-LPRIEILERSA 149
            :..:|.|.|::| :|..:..|...|::...:       .::.|:.:.:..|.: |...|||..|.
Mosquito    51 SACSTYFRELLK-STPCKHPVIVLQDVAFTDLHALVEFIYHGEVNVHQRSLSSFLKTAEILRVSG 114

  Fly   150 NTQENQDQLEGAARRLRKRLKAEDGSSV-------DKDKDED-GVEETAEPAP------------ 194
            .||:..::..|    :...|.|...|.|       :|..|:. .|.:.|.|.|
Mosquito   115 LTQQQAEETHG----MHASLGANLPSGVVHHPIYPEKMLDDSLYVSQGASPPPHLSSLHNSSSPN 175

  Fly   195 -------PKKRRGRP------RKSDAAVAPPQKPKEDIQLD---LKAEELDEFVDEETDP----D 239
                   .....|.|      :::.||.|..::....:..|   ||...:....:..|:|    |
Mosquito   176 SGGVGGGNSNGGGAPMVNQLLKRAAAAAALRRERNNSVHSDEMALKRHRMSVDSNGPTNPRDHLD 240

  Fly   240 FSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRE 304
            ..|..|...:             :||.....||..: ||              .|........::
Mosquito   241 VICSTPQTTA-------------TDFSSSAAKQHLS-LP--------------SPQGKDQMRQQD 277

  Fly   305 LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQV----------DPGYMM 359
            .|.........:.:..|   ::::..:|.|    |...:..::.|.:.:          ..|...
Mosquito   278 SLSGHANSSNSFSINSA---SNLIKSSINN----NNNNINNNNNLNNNLLHSKENSGVGGGGAGG 335

  Fly   360 CCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKL-------TFSC 417
            .||...:....|...   :.:.....||..::|..:|....|.:.|..:|...|       ..|.
Mosquito   336 LCGSGGSMPTSLGTS---NGSNAGSLCSAEKESLASSPSERSAEDVKSEPLELLCGTGGDHENSS 397

  Fly   418 DLCSKTF--LSKTAIDY---------HKLNK---HVPKSEFKFTCSECNKKFLTERKLKNHMSSM 468
            |..:...  |.|..:|.         |:|..   |...::|....|| ||.|.|.......|:::
Mosquito   398 DSVTDDHGDLVKGGLDVKGSLRSPNDHELESSMHHHSGAQFLMNASE-NKLFPTPPSFNFSMAAL 461

  Fly   469 -HDPESTIICDKCGKQMRTKIILKKHQELMHS---DKPRPEPELQQCQICGAWLKGMTGLKQHMK 529
             .||.:.       ....|:.:  :..||..|   :.|.| |..|.....|....||..|
Mosquito   462 AADPSAL-------AGFSTQAL--QAVELAGSPQGNMPLP-PTSQPSSTSGGGRHGMNRL----- 511

  Fly   530 SIHVESAGEHRCHICAKVSPNARALRRHIYHNH-ECERKFKCTMCEKAFKRPQELKEHTSTHTGE 593
            |:.:..|..|||.:|.|:......|:||....| :......|.:|.|.|:....|..|.|
Mosquito   512 SLPLPLAACHRCDVCGKLLSTKLTLKRHKEQQHLQPLNNAVCNLCHKVFRTLNSLNNHKS----- 571

  Fly   594 VLYTCPNCPMTFFCSANMYKHRQRL----HRAQY 623
                             :|..||::    |.|.:
Mosquito   572 -----------------IYHRRQKILHHHHHAHH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	14/52 (27%)
		FYDLN_acid	<191..268	CDD:302856	17/108 (16%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	3/17 (18%)
		LIM	361..>400	CDD:295319	7/38 (18%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	21/96 (22%)
		C2H2 Zn finger	417..438	CDD:275368	6/34 (18%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	3/20 (15%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	3/24 (13%)
AgaP_AGAP002165	XP_565666.4	BTB	22..118	CDD:279045	23/102 (23%)
		BTB	33..118	CDD:197585	19/91 (21%)
		C2H2 Zn finger	523..540	CDD:275368	5/16 (31%)
		C2H2 Zn finger	553..574	CDD:275368	7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910