DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and CG11696

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	184/648 - (28%)
Similarity:	290/648 - (44%)	Gaps:	91/648 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EVTTIVNQHFPVQISKESD---ERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQ 94
            ::..::.:|. :.:..|:|   ..:|.|||:.:::.......|:..|.||..:          .|
  Fly    30 QLAELIERHL-LLVLAENDVVSTCLCNRCWRQLAEIEQFCSMVAEKQRSLHRS----------LQ 83

  Fly    95 ETTSFPEIIKLATQE-------EEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQ 152
            ..|..||:.:|...|       .|...||:      ..|....|::|.| ..|.|:.|  ||..:
  Fly    84 LKTELPELPELTEPEPALVVWNTESPIEPK------LSYEGDDIKDHIL-CEPVIDAL--SAGDE 139

  Fly   153 ENQDQLEGAARRLRKRLKAEDGSSVDKD---KDEDGVEETAEPAPPKKR-RGRPRKSDAAVAPPQ 213
            ::.|.                |.:.:.|   :.:...||..||.|.|.| ||||||: |.....|
  Fly   140 KDSDY----------------GDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKT-ALQQTHQ 187

  Fly   214 --KPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAV 276
              |.|.:.:......::.|....|:......|..|...:|||  .|| |.|.:.|.|.|.:
  Fly   188 IIKRKYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDD--QDG-DEDEEDEEDVGGE---- 245

  Fly   277 LPKRTVVRPKKYKKRTKPAEPKVRM------SRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNL 335
            |......:||...||.:|...|:..      :.|:..:|...:|..|.|.|..   .|.||||..
  Fly   246 LTPDADEQPKPRGKRGRPKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANV---KLDCAICAA 307

  Fly   336 LVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLE 400
            .:.:|.:::||.|:.|.. .||:.||..::.:|.:..:|:..|.:|.:|.|..|.|:|.|    .
  Fly   308 PLEDFNDLKRHFRVEHDC-TGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLN----R 367

  Fly   401 SHQQVHM----DPAVKLTFSCDLCSKTFLSKTAIDYH-KLNKHVPKSEFKFTCSECNKKFLTERK 460
            :.|.:||    ....:|...|.:|...|..|..:..| |.:|...:.|   .|..|:|.|.|:.:
  Fly   368 NSQVMHMLRFHSQQQELVHQCAICEARFAKKFLLTMHLKGHKGTERPE---VCDTCSKTFRTKFE 429

  Fly   461 LKNHMSSMHDPEST-IICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGL 524
            |..|:..||..:.| ||||.||...|:|.....|::.:|.|.|..|   .||.:||.||:....|
  Fly   430 LSAHVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAE---VQCTLCGRWLRDERSL 491

  Fly   525 KQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHT 587
            ::|: :.|.:..|:  :||.:|.....:..||..|:.::|..:| .||::|:|.||.|:.|.||.
  Fly   492 RKHL-ARHDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKR-HKCSLCDKEFKLPRALAEHM 554

  Fly   588 STHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKPKQ 650
            :||||..||.|..|..||...|||:.|::::|...:....:||. .:|...:...:..|.|.|
  Fly   555 ATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPNDWVRKYSQPS-SSITSTAAPLAHPNHPNQ 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	11/50 (22%)
		FYDLN_acid	<191..268	CDD:302856	27/79 (34%)
		C2H2 Zn finger	330..351	CDD:275368	8/20 (40%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	22/80 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/21 (29%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	9/48 (19%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	8/24 (33%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	7/17 (41%)
		C2H2 Zn finger	478..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..583	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910