DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp513

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001012110.1	Gene:	Zfp513 / 313913	RGDID:	1310456	Length:	541	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	111/555 - (20%)
Similarity:	180/555 - (32%)	Gaps:	192/555 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PKKRRGRPR-------KSDAAVAPPQKP-----KEDIQL--DLKAEELDEFVDEETDPDFSCLVP 245
            |::::..|:       |.|...:..:.|     :.|:.|  ||:.||.:|  :||.|.....|:.
  Rat     2 PRRKQSHPQPVKCEGVKVDTEDSFDEGPGALVLESDLLLGQDLEFEEEEE--EEEGDGHNDQLMG 64

  Fly   246 SDNSSEDD--GGSDGFDSD-SDFELDNGKQEFAVLPKRTVVRPKKYKKRTK-------------- 293
            .:..||.|  |...|.... ||.|...|:   |:..:..|..|.:.....:
  Rat    65 FERDSEGDSQGARPGLPYGLSDDESGGGR---ALSAESEVEEPARGPGEARGERPGPACQLCGGP 126

  Fly   294 ----------------PAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTE 342
                            |..|::..|                           |.:|..:.|..:.
  Rat   127 TGEGPCCGAGGPGGGPPLPPRLLYS---------------------------CRLCAFVSHYSSH 164

  Fly   343 MQRHHRLTHQVDPGYMMCCGR---KFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQ 404
            ::||.: ||..:..:.  |||   ...|...|..|...|.....::|..|..:..:..:|..||:
  Rat   165 LKRHMQ-THSGEKPFR--CGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQR 226

  Fly   405 VHMDPAVKLTFSCDLC--------------------SKTFLSKTAIDYHKLNKHVPK-------- 441
            .|..|.   |..|..|                    :....|:.|:....|:.|||.
  Rat   227 THTGPP---TPPCPTCGFRCCAPRPTRPPSPTEQEGTMPRRSEDALILPDLSLHVPPGGTSFLPD 288

  Fly   442 ---------------SE------FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMR 485
                           ||      |.:||..|.:: |.|.:.....::|           ||:.||
  Rat   289 CGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQE-LEEGEGSRLGTAM-----------CGRCMR 341

  Fly   486 TKI-----------------------------ILKKHQELMHSDKPRPEPELQQCQICGAWLKGM 521
            .:.                             .|.:|.:....:||      .:|..|......:
  Rat   342 GESGGGGSGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKP------FRCARCPYASAHL 400

  Fly   522 TGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELK 584
            ..||:|.: :|   .||  ::|.:|.....|...|:|| ...|..::.|:|::|..:..:...||
  Rat   401 DNLKRHQR-VH---TGEKPYKCPLCPYACGNLANLKRH-GRIHSGDKPFRCSLCNYSCNQSMNLK 460

  Fly   585 EHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            .|...||||..:.|..|..|.....| ||..|::|
  Rat   461 RHMLRHTGEKPFRCATCAYTTGHWDN-YKRHQKVH 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	24/89 (27%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/20 (30%)
		LIM	361..>400	CDD:295319	9/41 (22%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	23/124 (19%)
		C2H2 Zn finger	417..438	CDD:275368	5/40 (13%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	6/49 (12%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp513	NP_001012110.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		28/122 (23%)
		C2H2 Zn finger	152..172	CDD:275368	5/20 (25%)
		zf-H2C2_2	164..189	CDD:290200	7/27 (26%)
		COG5048	176..>228	CDD:227381	12/53 (23%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		zf-H2C2_2	192..217	CDD:290200	5/24 (21%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		COG5048	<372..>450	CDD:227381	21/88 (24%)
		zf-H2C2_2	374..399	CDD:290200	6/30 (20%)
		C2H2 Zn finger	390..410	CDD:275368	5/20 (25%)
		zf-H2C2_2	402..425	CDD:290200	8/26 (31%)
		COG5048	414..>487	CDD:227381	21/74 (28%)
		C2H2 Zn finger	418..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	458..481	CDD:290200	9/22 (41%)
		C2H2 Zn finger	474..493	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..541		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100