DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp64

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001012093.1	Gene:	Zfp64 / 311661	RGDID:	1307948	Length:	678	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	107/485 - (22%)
Similarity:	174/485 - (35%)	Gaps:	104/485 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDS------- 263
            ||.||..|...:.....:.|....:||.|||.|    ..|:..::..      ..|::
  Rat    44 DAFVAHKQSGCQLTTTPVTAPSTVQFVSEETVP----ATPTQTATTT------ISSETQTITVAA 98

  Fly   264 -DFELDNGKQEFAVLPKRT--------VVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVI 319
             :|..::|.|.:  ||..:        :..|.|.:.: ||..|..        |:|
  Rat    99 PEFVFEHGYQTY--LPTESTDDQTATVIALPTKTRTK-KPTAPPA--------QKK--------- 143

  Fly   320 IAKFFTSVLPCAI--CNL-LVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNP 381
                    |.|..  |.. ..:...:|:||.::.....|.....||:.|:::..|..|:..|...
  Rat   144 --------LGCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGV 200

  Fly   382 DHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKF 446
            ..:||..|:.:..:|..|..|.::|.|   :..|.|.:|.....:.:.:..| |..|.  .:..|
  Rat   201 KPYKCKTCDYAAADSSSLNKHLRIHSD---ERPFKCQICPYASRNSSQLTVH-LRSHT--GDAPF 259

  Fly   447 TCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQC 511
            .|..|:.||.....||.|| .:|..|....||.|..:...|..||.|..:.||......|   .|
  Rat   260 QCWLCSAKFKISSDLKRHM-RVHSGEKPFKCDFCNVRCTMKGNLKSHIRIKHSGNNFKCP---HC 320

  Fly   512 QICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKA 576
            ...|   ...:.|::|.: :| :|....:|..|:....:..|||.| ...|..||.|||:.|...
  Rat   321 DFLG---DSKSTLRKHSR-LH-QSEHPEKCAECSYSCSSKAALRVH-ERIHCTERPFKCSYCSFD 379

  Fly   577 FKRPQELKEHTSTHTGEVL--------------------------YTCPNCPMTFFCSANMYKHR 615
            .|:|..|.:|......:.|                          :.|..|..:|     |.:..
  Rat   380 TKQPSNLSKHMKKFHADTLKNEAPERKDSGRQSSRQVAKLDAKKTFHCDICDASF-----MREDS 439

  Fly   616 QRLHRAQYEADKNQPKPPNILKISRNASTQ 645
            .|.|:.|:....::.....::::....|.|
  Rat   440 LRSHKRQHSEYHSKNSDVTVVQLHLEPSKQ 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	15/69 (22%)
		C2H2 Zn finger	330..351	CDD:275368	5/23 (22%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
Zfp64	NP_001012093.1	COG5048	<151..450	CDD:227381	77/319 (24%)
		zf-H2C2_2	161..186	CDD:290200	7/24 (29%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		zf-H2C2_2	190..211	CDD:290200	6/20 (30%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-H2C2_2	217..239	CDD:290200	7/24 (29%)
		C2H2 Zn finger	233..253	CDD:275368	4/20 (20%)
		C2H2 Zn finger	261..281	CDD:275368	8/20 (40%)
		zf-H2C2_2	273..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	345..365	CDD:275368	6/20 (30%)
		zf-H2C2_2	357..382	CDD:290200	11/25 (44%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
		zf-C2H2_6	424..450	CDD:290623	7/30 (23%)
		C2H2 Zn finger	427..447	CDD:275368	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030