DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp354c

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_038950.3	Gene:	Zfp354c / 30944	MGIID:	1353621	Length:	560	Species:	Mus musculus

Alignment Length:	509	Identity:	131/509 - (25%)
Similarity:	203/509 - (39%)	Gaps:	91/509 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 NQDQ---LEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKP 215
            :||:   |:.|.|.|.:.:..|:.|::    ...|.:.:..|...|.::|
Mouse    24 SQDEWLHLDPAQRSLYREVMLENYSNL----ASLGFQASIPPVIGKLQKG--------------- 69

  Fly   216 KEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPK- 279
             :|..::.:|.| |..:|.|..|:...|.|..:....: .|.|...:...:....|..|..|.|
Mouse    70 -QDPCMEREAPE-DTCLDFEIWPEIEALPPKQDVLTKE-TSHGLIKNGSTKCVYWKISFGELVKT 131

  Fly   280 --RTVVRPKKYK---------KRT----------KPAEPKVRMSRELLEQRKKQQEEYDVIIAKF 323
              |.:.:.::.|         |.|          :|.:| :.:|:.|:.|.....|.   :.|.:
Mouse   132 ECRDIAQEQEKKVHGPGAESPKETTSEDGTPTGFEPEKP-LFISKALVSQEGDPTES---VPATY 192

  Fly   324 FTSV--LPCAICNLLVHNFTEMQRHHRLTHQVDPGYM--MC--CGRKFTQRKVLAEHVLVHWNPD 382
            .||.  ||        .:|..|:     :.|:.||..  :|  ||:.|||...|.||..:|....
Mouse   193 HTSEKDLP--------QDFDLMR-----SFQMYPGQKPHVCSECGKGFTQSLHLLEHKRLHTGEK 244

  Fly   383 HFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFT 447
            .:|||.|.|||.:...|.:||:.|..   :..:.|..|.|.|.|.:.:..| |..|.  .|..:.
Mouse   245 PYKCSECGKSFSHRSSLLAHQRTHTG---EKPYKCSECEKAFGSSSTLIKH-LRVHT--GEKPYR 303

  Fly   448 CSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQ 512
            |.:|.|.|.....|..| ..:|..|....|.:|.|....:..|.:||.:...:||      .:|.
Mouse   304 CRQCGKAFSQCSTLTVH-QRIHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKP------YKCA 361

  Fly   513 ICGAWLKGMTGLKQHMKSIHVESAGEHRCHI--CAKVSPNARALRRHIYHNHECERKFKCTMCEK 575
            .||........|.:|.: :|   .||..|..  |.:.......|..| ...|..::.::|..|.|
Mouse   362 ECGKGYSQFPSLAEHQR-LH---TGEQLCQCLQCGRTFTRVSTLIEH-QRIHTGQKPYQCNECGK 421

  Fly   576 AFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQ 629
            .|.:.....||...||||.||||..|...|.|.:|:|:| ||:|..:.....||
Mouse   422 TFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRH-QRIHTGEKPYQCNQ 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	360..378	CDD:275368	9/19 (47%)
		LIM	361..>400	CDD:295319	16/38 (42%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	4/22 (18%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
Zfp354c	NP_038950.3	KRAB	14..74	CDD:214630	13/69 (19%)
		KRAB	14..53	CDD:279668	8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..168		3/28 (11%)
		COG5048	204..>543	CDD:227381	88/295 (30%)
		C2H2 Zn finger	220..240	CDD:275368	9/19 (47%)
		zf-H2C2_2	232..257	CDD:290200	11/24 (46%)
		C2H2 Zn finger	248..268	CDD:275368	9/19 (47%)
		zf-H2C2_2	260..283	CDD:290200	7/25 (28%)
		C2H2 Zn finger	276..296	CDD:275368	7/20 (35%)
		zf-H2C2_2	289..313	CDD:290200	8/26 (31%)
		C2H2 Zn finger	304..324	CDD:275368	6/20 (30%)
		zf-H2C2_2	317..341	CDD:290200	7/24 (29%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	347..369	CDD:290200	7/27 (26%)
		C2H2 Zn finger	360..380	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	3/20 (15%)
		zf-H2C2_2	401..425	CDD:290200	7/24 (29%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	11/22 (50%)
		C2H2 Zn finger	444..464	CDD:275368	9/20 (45%)
		zf-H2C2_2	456..481	CDD:290200	8/20 (40%)
		C2H2 Zn finger	472..492	CDD:275368	2/3 (67%)
		zf-H2C2_2	485..509	CDD:290200
		C2H2 Zn finger	500..520	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910