DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp521

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_038952847.1	Gene:	Zfp521 / 307579	RGDID:	1307345	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	131/629 - (20%)
Similarity:	209/629 - (33%)	Gaps:	215/629 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDE 234
            |.|||.:||..|..|..||..|.|        ....|:.:...:...:..:..:...:|.:.||.
  Rat    22 KIEDGEAVDCKKRPDDGEELEEDA--------VHSCDSCLQVFESLSDITEHKIHQCQLTDGVDV 78

  Fly   235 ETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAV-LPKRTVVRPKKYKKRTKPAEPK 298
            |.||  :|..|:.:.|..|..|.......||    |::|... ||.......|.:.:
  Rat    79 EDDP--TCSWPASSPSSKDQTSPSHGEGCDF----GEEEGGPGLPYPCQFCDKSFSR-------- 129

  Fly   299 VRMSRELLEQRKKQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC- 360
                   |...|..::.:        :..||  |..|:.|..:.....||.:| |..|..| .|
  Rat   130 -------LSYLKHHEQSH--------SDKLPFKCTYCSRLFKHKRSRDRHIKL-HTGDKKY-HCS 177

  Fly   361 -CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH-------------MDPAV 411
             |...|::...|..|:..|.:...:||:||.:.|.:|..|..|.|||             .|..:
  Rat   178 ECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLHGHMQVHERSKDGSQSGSRMEDWKM 242

  Fly   412 KLTFSCDLCSKTF-----LSKTAIDYH-------------------------KLNKHVPK---SE 443
            |.|..|..|.:.|     |.|...:.|                         .|..|:.:   .|
  Rat   243 KDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHIEQVHGGE 307

  Fly   444 FKFTCSECNKKFLTERKLKNHMSSMHDPES----------------------------------- 473
            .|.:||.|::.|||..:|.:||.|...|||
  Rat   308 KKNSCSICSESFLTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVE 372

  Fly   474 -------------------------------TIICDKCGKQMRTKI-ILKKHQELMHSDKPRPEP 506
                                           |..|..|.||:.:.: :|:.|.:.||.|||.
  Rat   373 AAPPIPKSRGRKRAAQQTSDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPE--- 434

  Fly   507 ELQQCQICGAWLKGMTGLKQHMKSIH-------VESAGE---HRCHICAKVSPNARALRRHIYHN 561
            :...||.|...|..:..|.:|:|.:|       :.||..   ::|:.|::|..:...|:.||
  Rat   435 QAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIIYQCNFCSEVVNDLNTLQEHI--- 496

  Fly   562 HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEAD 626
                      .|...|..|.....:.        :.||:|.|.|...:::.:|.:::| ......
  Rat   497 ----------RCSHGFANPAAKDSNA--------FFCPHCYMGFLTDSSLEEHIRQVH-CDLSGS 542

  Fly   627 K------NQPKPP-----------------NILKISRNASTQNK 647
            :      ..||.|                 ::||::::....:|
  Rat   543 RFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/76 (21%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	28/121 (23%)
		C2H2 Zn finger	417..438	CDD:275368	7/50 (14%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/21 (29%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	3/19 (16%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
Zfp521	XP_038952847.1	COG5048	<84..236	CDD:227381	42/180 (23%)
		C2H2 Zn finger	120..140	CDD:275368	3/34 (9%)
		C2H2 Zn finger	148..168	CDD:275368	6/20 (30%)
		C2H2 Zn finger	176..196	CDD:275368	5/19 (26%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	407..428	CDD:275368	6/20 (30%)
		C2H2 Zn finger	439..460	CDD:275368	7/20 (35%)
		C2H2 Zn finger	479..498	CDD:275368	6/31 (19%)
		C2H2 Zn finger	636..656	CDD:275368
		C2H2 Zn finger	666..686	CDD:275368
		C2H2 Zn finger	696..713	CDD:275368
		C2H2 Zn finger	724..745	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		COG5236	785..>964	CDD:227561
		C2H2 Zn finger	785..805	CDD:275368
		C2H2 Zn finger	811..829	CDD:275368
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910