DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp407

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_008770443.2	Gene:	Zfp407 / 307213	RGDID:	1310645	Length:	2255	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	146/629 - (23%)
Similarity:	220/629 - (34%)	Gaps:	179/629 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CEYPAMMGDYIDVHSARGDQLEVTTIV--NQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSA 74
            ||..:  .|..||.:  ...||...|:  :||.|..|.:|......|                :|
  Rat  1277 CEQTS--EDLKDVQA--NSNLESKEILMNSQHEPEVILEEDAPASIG----------------TA 1321

  Fly    75 AQSSLQETKVALMEDDPLTQETTSF----PEIIKLATQEEEGVTEPQE----LGGRNFFYPEIKI 131
            ..:...||.:::   |...|...||    ..||::.|::.|.|.:|:|    .||        |:
  Rat  1322 ENNDAYETIISI---DDKGQTMYSFGRFDSSIIRIKTEDGELVEQPEEGLMVTGG--------KV 1375

  Fly   132 EEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDK----DE-----DGVE 187
            .|     ||                 |:..|:.|:|  |..:|||..:..    |:     ||:.
  Rat  1376 SE-----LP-----------------LKDCAQGLKK--KKVEGSSFGESTRIRCDDCGFLADGLS 1416

  Fly   188 ----ETAEPAPPKKRR-----------------------GRPRKSDAAVAPPQKPKEDIQLDLKA 225
                ..|...|.|::.                       |..|...|:|
  Rat  1417 GLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASV---------------- 1465

  Fly   226 EELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKK 290
            |||     .|....|.|:          ..::.|||:.:..|....|...:|  |.|   .||
  Rat  1466 EEL-----PEGGATFKCV----------KCTEPFDSEQNLFLHIKGQHEELL--REV---NKY-- 1508

  Fly   291 RTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQ--RHHRLTHQV 353
                       ..|..||..:::||....:.|:         |..:..:...|.  .|.|.....
  Rat  1509 -----------IVEDTEQINREREENQGNVCKY---------CGKMCRSSNSMAFLAHIRTHTGS 1553

  Fly   354 DPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESH--QQVHMDPAVKLTFS 416
            .|.....|.....|......||..|.....:||.||..:|...:||.:|  .:..:....:..|:
  Rat  1554 KPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFT 1618

  Fly   417 CDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCG 481
            |.||.::|..|.|::.| :..|..:..||.|...|:..|||...:|:|..: |..|.:.:||.||
  Rat  1619 CHLCDRSFTEKWALNNH-VKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRT-HTGEKSFLCDLCG 1681

  Fly   482 KQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHIC 544
            ....|:..|.||:.....:||      .:|..|.......:.|.:| |.:|   .||  :||..|
  Rat  1682 FAGGTRHALTKHRRQHTGEKP------FKCDECNFASTTQSHLTRH-KRVH---TGEKPYRCPWC 1736

  Fly   545 AKVSPNARALRRHIYH--NHECERKFKCTMCEKAFKRPQELKEH 586
            ...|..|..:|:||.|  .||..:.:.|..|:.....|.|.:.|
  Rat  1737 DYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNVPVEFRNH 1780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/70 (21%)
		FYDLN_acid	<191..268	CDD:302856	15/99 (15%)
		C2H2 Zn finger	330..351	CDD:275368	4/22 (18%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	7/21 (33%)
		zf-C2H2_8	389..465	CDD:292531	22/77 (29%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	8/22 (36%)
		C2H2 Zn finger	570..590	CDD:275368	5/17 (29%)
		C2H2 Zn finger	598..619	CDD:275368
Zfp407	XP_008770443.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100