DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF454

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001171560.1	Gene:	ZNF454 / 285676	HGNCID:	21200	Length:	522	Species:	Homo sapiens

Alignment Length:	576	Identity:	144/576 - (25%)
Similarity:	225/576 - (39%)	Gaps:	114/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQD 156
            :.||:.:|.::..|.||||.|...|    .:...|.::.:|.:  ..|..:.:|....:|   ..
Human     9 MVQESVTFKDVAILFTQEEWGQLSP----AQRALYRDVMLENY--SNLVSLGLLGPKPDT---FS 64

  Fly   157 QLEGAARRLRKRLKAED---GSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKED 218
            |||     .|:....||   |..:|                             .:..|...|..
Human    65 QLE-----KREVWMPEDTPGGFCLD-----------------------------WMTMPASKKST 95

  Fly   219 IQLDLKAEELDEFVDEE---TDPDFSCLV--------------------PSDNSSE-DDGG---- 255
            ::.::..||||::..:|   :...:.|..                    |:..|.| |:.|
Human    96 VKAEIPEEELDQWTIKERFSSSSHWKCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMS 160

  Fly   256 -------SDGFD-SDSDFELDN-GKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRK- 310
                   |.||. |.:.||... ||    |..|.:.:...:.....|.|..|:.:..:..|.|:
Human   161 SSLHSDQSQGFQPSKNAFECSECGK----VFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECREC 221

  Fly   311 ---KQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKV 370
               ..|..:.:...:..|...|  |..|.......:.:..|.::.....|.....||:.|.:...
Human   222 GKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKAFIRNIH 286

  Fly   371 LAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKL 435
            ||.|..:|.....|||::|||:|....||..||.:|   :.:..:.|:.|.|.|...|:...|
Human   287 LAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIH---SGEKPYKCNECGKAFNQSTSFLQH-- 346

  Fly   436 NKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSD 500
             :.:...|..|.|:||.|.|.....|..| ..:|..|....|::|||..|......:|:::...:
Human   347 -QRIHTGEKPFECNECGKAFRVNSSLTEH-QRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGE 409

  Fly   501 KPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHE 563
            ||      .:|.:|....:..:.|.||.: ||   .||  :.|:||.|...:..||.:| ...|.
Human   410 KP------YRCGLCEKAFRDQSALAQHQR-IH---TGEKPYTCNICEKAFSDHSALTQH-KRIHT 463

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            .|:.:||.:|||||.|...|.:|...||||..|.|..|...|..:||:.:| ||.|
Human   464 REKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQH-QRHH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	19/112 (17%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
ZNF454	NP_001171560.1	KRAB	14..73	CDD:214630	17/72 (24%)
		KRAB	14..53	CDD:279668	11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..170		5/22 (23%)
		zf-C2H2	178..200	CDD:278523	6/25 (24%)
		C2H2 Zn finger	180..200	CDD:275368	4/23 (17%)
		COG5048	186..522	CDD:227381	100/352 (28%)
		C2H2 Zn finger	218..238	CDD:275368	2/19 (11%)
		zf-H2C2_2	230..254	CDD:290200	4/23 (17%)
		C2H2 Zn finger	246..266	CDD:275368	3/19 (16%)
		zf-H2C2_2	258..283	CDD:290200	5/24 (21%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..311	CDD:290200	11/24 (46%)
		C2H2 Zn finger	302..322	CDD:275368	9/19 (47%)
		zf-H2C2_2	314..339	CDD:290200	9/27 (33%)
		C2H2 Zn finger	330..350	CDD:275368	6/22 (27%)
		zf-H2C2_2	342..365	CDD:290200	7/25 (28%)
		C2H2 Zn finger	358..378	CDD:275368	7/20 (35%)
		zf-H2C2_2	370..393	CDD:290200	8/23 (35%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-H2C2_2	398..421	CDD:290200	5/28 (18%)
		C2H2 Zn finger	414..434	CDD:275368	5/20 (25%)
		zf-H2C2_2	426..450	CDD:290200	11/27 (41%)
		C2H2 Zn finger	442..462	CDD:275368	7/20 (35%)
		zf-H2C2_2	454..479	CDD:290200	12/25 (48%)
		C2H2 Zn finger	470..490	CDD:275368	9/19 (47%)
		zf-H2C2_2	482..507	CDD:290200	10/24 (42%)
		C2H2 Zn finger	498..518	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910