DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF544

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001374339.1	Gene:	ZNF544 / 27300	HGNCID:	16759	Length:	769	Species:	Homo sapiens

Alignment Length:	489	Identity:	123/489 - (25%)
Similarity:	181/489 - (37%)	Gaps:	114/489 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 QKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSD---SDFELDNGKQEF 274
            |||   :.......|.||.  .||..:..|||.::.|..   |...|..:   :.|.:.:...:.
Human   342 QKP---VHFGKSQYECDEC--RETCSESLCLVQTERSGP---GETPFRCEERCAAFPMASSFSDC 398

  Fly   275 AVLPKRTVVRP-------------KKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTS 326
            .::  :|..:|             |...:||...|...    |..:..|...:.||::|
Human   399 NII--QTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKPF----ECTQCGKSFSQSYDLVI------ 451

  Fly   327 VLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
                                |:.||..:..| .|  ||:.||||..|..|..:|.....::|..|
Human   452 --------------------HQRTHTGEKPY-ECDLCGKSFTQRSKLITHQRIHTGEKPYQCIEC 495

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKK 454
            .|||:.:.:|..||::|..   :..:.|..|.|:|.....:..|| ..|..:..||  |::|.|.
Human   496 RKSFRWNSNLIVHQRIHTG---EKPYECTHCGKSFSQSYELVTHK-RTHTGEKPFK--CTQCGKS 554

  Fly   455 FLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLK 519
            |..:..|..|..: |..|....|:.|||.......|..||.:...:||      .||..||...:
Human   555 FSQKYDLVVHQRT-HTGEKPYECNLCGKSFSQSSKLITHQRIHTGEKP------YQCIECGKSFR 612

  Fly   520 GMTGLKQHMKSIHV-------------------------ESAGE--HRCHICAKVSPNARALRRH 557
            ..:.|..|.: ||.                         ...||  :.|:.|.|....:..|.||
Human   613 WNSNLVIHQR-IHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQLIRH 676

  Fly   558 IYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            : ..|..|:.:||..|.|||.|...|..|..|||||..:.|..|...|..|:|:..| .|:|..:
Human   677 L-QIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSH-HRIHSGE 739

  Fly   623 --YEAD------KNQPKPPNILKISRNASTQNKP 648
              ||..      :.|.:    |.:.|...|..||
Human   740 KPYECSDCGKSFRQQSQ----LVVHRRTHTGEKP 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	15/57 (26%)
		C2H2 Zn finger	330..351	CDD:275368	1/20 (5%)
		C2H2 Zn finger	360..378	CDD:275368	9/19 (47%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630
		C2H2 Zn finger	410..428	CDD:275368	2/17 (12%)
		zf-H2C2_2	424..445	CDD:404364	5/24 (21%)
		C2H2 Zn finger	436..456	CDD:275368	5/45 (11%)
		COG5048	460..>753	CDD:227381	88/309 (28%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		C2H2 Zn finger	520..540	CDD:275368	6/20 (30%)
		C2H2 Zn finger	548..568	CDD:275368	6/20 (30%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	5/20 (25%)
		C2H2 Zn finger	632..652	CDD:275368	0/19 (0%)
		C2H2 Zn finger	660..680	CDD:275368	6/20 (30%)
		C2H2 Zn finger	688..708	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..736	CDD:275368	7/20 (35%)
		C2H2 Zn finger	744..764	CDD:275368	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910