DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zbtb11

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_766614.2	Gene:	Zbtb11 / 271377	MGIID:	2443876	Length:	1050	Species:	Mus musculus

Alignment Length:	650	Identity:	147/650 - (22%)
Similarity:	240/650 - (36%)	Gaps:	155/650 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TLHEFVSAAQSSLQETKVALM--------------EDDPLTQETTSFPEIIKLATQEEEGVTEPQ 117
            |.:|..:.....|...::.|:              |..|..|.:   || .:.:....||:.||
Mouse   345 TRNEATTTLSGELGHCEIVLLVNGELPEAEQNGEPEQQPAPQAS---PE-AEASVSPVEGIPEP- 404

  Fly   118 ELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKD 182
                    :||:...     :|.:......||.|:|     :|....:..::..|:.::..::..
Mouse   405 --------HPEMGTA-----SLAKESNQPESAVTRE-----DGIVASVHPKISKENVTNASQEDS 451

  Fly   183 EDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSD 247
            :.|.:.:.|..      |.....|.:.:|.|..|::..|....|:.|...|::|...     ...
Mouse   452 DTGNDTSPEDI------GAKDCPDHSQSPGQPSKDEDTLTEATEKTDSGPDDDTYRS-----RLR 505

  Fly   248 NSSEDDGGSDGFDSDSDFELDNGK--QEFAV--LPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQ 308
            ..|.::||........:.:|...|  .:.||  :.::.|.|.||.|      :|| |.::|..|:
Mouse   506 QRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMK------QPK-RDAKESTEE 563

  Fly   309 RKKQQEEYDVIIAKFFTSVL-----------PCAIC------------NLLVH-----------N 339
            ...:..|..::..:.:..::           .|.:|            :|:.|           |
Mouse   564 TAHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKEAPTSSSSN 628

  Fly   340 FTEMQ------------------------------RHHRLTHQ-VDPGYMMCCGRKFTQRKVLAE 373
            .|..:                              |.|.|.|. |.|.....||:.|..:..|..
Mouse   629 STSTEASGGSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKL 693

  Fly   374 HVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH 438
            |..:|.:...|:|.:|.|||...|.|:.|..:|...:   .:.|.:|.|:|...:.:..| |.||
Mouse   694 HQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGES---KYFCSICGKSFHRGSGLSKH-LKKH 754

  Fly   439 VPKSEFK-FTCSECNKKFLTERKLKNHMSSMH---DPESTIICDKC---GKQMRTKIILKKHQEL 496
            .||.|.: :.|::|.|.|...|.|:.||:. |   .|.....||||   .|...:.:  |.|..
Mouse   755 QPKPEVRGYHCTQCEKSFFEARDLRQHMNK-HLGVKPFQCQFCDKCYSWKKDWYSHV--KSHSV- 815

  Fly   497 MHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAG------EHRCHICAKVSPNARALR 555
                   .||  .:|.|||.........::|:|.......|      |..|..|.:.....|..|
Mouse   816 -------TEP--YRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYR 871

  Fly   556 RHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHR 620
            ||: :|||..:.|:|..|..|:...:.||.|..|||||..|.||.|...:..:..:.||..:.||
Mouse   872 RHM-NNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHR 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	3/13 (23%)
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	9/73 (12%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	25/76 (33%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/23 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
Zbtb11	NP_766614.2	Integrase_H2C2	68..120	CDD:375431
		BTB_POZ_ZBTB11	195..312	CDD:349511
		Trypan_PARP	<367..>421	CDD:392002	12/71 (17%)
		C2H2 Zn finger	568..588	CDD:275368	1/19 (5%)
		C2H2 Zn finger	596..616	CDD:275368	3/19 (16%)
		C2H2 Zn finger	650..670	CDD:275368	3/19 (16%)
		COG5048	<664..837	CDD:227381	56/189 (30%)
		C2H2 Zn finger	678..698	CDD:275368	5/19 (26%)
		C2H2 Zn finger	706..726	CDD:275368	8/19 (42%)
		C2H2 Zn finger	734..754	CDD:275368	6/20 (30%)
		C2H2 Zn finger	765..785	CDD:275368	8/20 (40%)
		C2H2 Zn finger	793..813	CDD:275368	6/21 (29%)
		C2H2 Zn finger	857..877	CDD:275368	6/20 (30%)
		C2H2 Zn finger	885..905	CDD:275368	6/19 (32%)
		zf-H2C2_2	897..920	CDD:372612	12/22 (55%)
		C2H2 Zn finger	913..934	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910