DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp335

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001093956.2	Gene:	Zfp335 / 259270	RGDID:	628751	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	123/565 - (21%)
Similarity:	188/565 - (33%)	Gaps:	180/565 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 TQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKA 171
            |.||||              ||.:.|:.::.....|:.||..::....:|:..|...||::
  Rat   297 TTEEEG--------------PEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQR---- 343

  Fly   172 EDGSSVDKDKDEDGVEETAEPAP----PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFV 232
                                |.|    |::|.|||||.      |:....|:. |...|.|....
  Rat   344 --------------------PTPSTLRPRRRPGRPRKL------PRLETSDLH-DGIGEPLVSSQ 381

  Fly   233 DEETDPDFSCLVPSDNSSEDDGGSDGFD------SDSDFELDNGK---QEFAVLPKRTVVRP--- 285
            ..::.|:...|....:|.....|..|..      |.||.|  |..   |:.|.:|.|...||
  Rat   382 STQSPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAE--NAAPSCQDEADVPPRRRGRPSRR 444

  Fly   286 ---KKYKK-RTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP--CAIC--NLLVHNFTE 342
               |||:| ..|..:|.:|                            |  |.||  ..|.|   |
  Rat   445 FLGKKYRKYYYKSPKPLLR----------------------------PYLCRICGSRFLSH---E 478

  Fly   343 MQRHHRLTHQV-DPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQ 404
            ..|.|..:|:. ||....|  |..:..:...|.||:..|.....:||..|..:....:.:..|..
  Rat   479 DLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAA 543

  Fly   405 VHM-------DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLK 462
            ||.       ||..||:                              .|.|..|.:.:..:::|.
  Rat   544 VHSQDRKKRPDPTPKLS------------------------------SFPCPVCGRVYPMQKRLT 578

  Fly   463 NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            .||.: |..|...:||||||..:.:...|.|                              |..|
  Rat   579 QHMKT-HSTEKPHMCDKCGKSFKKRYTFKMH------------------------------LLTH 612

  Fly   528 MKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST-HT 591
            ::::   :....:|..|..|..:.:||..| ..:|..::.|||:.|.....|...|..|.:. ||
  Rat   613 IQAV---ANRRFKCEFCEFVCEDKKALLNH-QLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHT 673

  Fly   592 GEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYE--ADKNQPKPPN 634
            |...:.|..|..:.....|:..|.:..|...:|  ..::..:||:
  Rat   674 GAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPS 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	23/86 (27%)
		C2H2 Zn finger	330..351	CDD:275368	8/22 (36%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	12/82 (15%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	3/16 (19%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	5/20 (25%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
Zfp335	NP_001093956.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..398		31/145 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..442		10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030