DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp180

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_653358.2	Gene:	Zfp180 / 246279	RGDID:	631380	Length:	727	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	179/774 - (23%)
Similarity:	269/774 - (34%)	Gaps:	244/774 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISKESDERICGRCWKIVSDF------------HTLHEFVSAAQSSLQETKVALMEDDPLTQETTS 98
            :...|..|:||......||.            |:.|  |..|..|.||   ||        .||.
  Rat    21 VKAPSVARLCGWAQSARSDLADADSKWRPDPGHSNH--VGCASGSGQE---AL--------GTTP 72

  Fly    99 FPEIIKLATQEEEGVTEPQELGG--RNFFYPEIKIEEHE------LDTLPR---------IEILE 146
            .||    .|.|::....|:.|..  .||..|:..|.|.|      ||.||:         :::.|
  Rat    73 HPE----GTMEQQDDESPETLQACVENFVLPQEMIIEVEGEDAGSLDILPQESTDFKIVTVDLTE 133

  Fly   147 -------RSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETA--------EPAPPK 196
                   ::..|.|....|.|..|.|      .|.::|.:      .|||.        ||:...
  Rat   134 EGQSTWSKAQRTPERPVTLAGPGRDL------WDSTAVHR------TEETTSKQTVFDEEPSHGS 186

  Fly   197 KRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEET-----------------DPDF--SC 242
            |             |....::|..|....|:|::..|::.                 ||.|  ||
  Rat   187 K-------------PEVLARDDPWLSSCEEQLEKQQDKQEEGVLTQGSAGPPETVYGDPGFDRSC 238

  Fly   243 L---------VP-------------------SDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPK 279
            |         :|                   :::..:.:..:|.|:.|.     :||...::.|.
  Rat   239 LSTSRPSFPMIPLRNHFHKQASHVKKLHGDVANSHQQINNNADFFEDDK-----SGKVPQSLHPT 298

  Fly   280 RTVVRPK-----KYKKRTKP--------AEPKVRMSRE----------------LLEQRKKQQEE 315
            :.:..||     ::..|.:|        ...||.:..:                |.||:|...:|
  Rat   299 QCIRTPKGKKACEFNGRVQPFGQGVPLNLNQKVHLEGKSFGFKGRGQVLNRNIVLNEQQKLLIKE 363

  Fly   316 YDVIIAKFFTSVLPCAICNLLVHNFTEMQRH-----------------HRLTHQVDPGYM--MC- 360
            .....:|  |:..|....||  .|::|.:|.                 |:.||..:..|.  :|
  Rat   364 GQYKCSK--TAPSPSLPQNL--RNYSEEKRFECKYCGKSFSWSSHLIAHQRTHTGEKPYKCNLCG 424

  Fly   361 --------------------------CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHL 399
                                      ||:.||||.||..|...|.....::|:.|.|||:.|..|
  Rat   425 KFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQRTHTGERPYECNQCGKSFRQSYKL 489

  Fly   400 ESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH--VPKSEFKFTCSECNKKFLTERKLK 462
            .:||:.|..   :..:.|..|.|:|     |..:||..|  :...|..:.||.|.|.|....||.
  Rat   490 IAHQRTHTG---EKPYECTQCGKSF-----IQSYKLIAHQKIHSGEKPYECSHCGKSFSQSYKLV 546

  Fly   463 NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            .|..: |..|....|:.|||.......|..||.....:||      .:|..||......:.|..|
  Rat   547 AHQRT-HTGEKPFECNYCGKSFSWSSQLVSHQRTHTGEKP------YECNECGKSFNRSSHLVMH 604

  Fly   528 MKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTH 590
            .::    ..||  ::|..|.|....:..|..| ...|..|:.::|..|.|.|::.....:|..||
  Rat   605 QRT----HTGEKPYQCKQCGKSFSQSYVLVVH-QRTHTGEKPYECGQCGKTFRQSSCFTQHQRTH 664

  Fly   591 TGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YEADKNQPKPPNILKISRNASTQNK 647
            |||..|.|..|..||..||.:..| ||.|..:  |:..:......:..|.||:.:|.::
  Rat   665 TGEKPYECNQCGKTFSLSARLIVH-QRTHTGEKPYKCSQCGKAFISSSKRSRHQATHSE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	11/46 (24%)
		FYDLN_acid	<191..268	CDD:302856	19/123 (15%)
		C2H2 Zn finger	330..351	CDD:275368	6/37 (16%)
		C2H2 Zn finger	360..378	CDD:275368	10/44 (23%)
		LIM	361..>400	CDD:295319	16/38 (42%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	25/77 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
Zfp180	NP_653358.2	C2H2 Zn finger	368..384	CDD:275368	5/19 (26%)
		COG5048	369..723	CDD:227381	101/379 (27%)
		zf-C2H2	390..412	CDD:278523	1/21 (5%)
		C2H2 Zn finger	392..412	CDD:275368	1/19 (5%)
		zf-H2C2_2	404..429	CDD:290200	5/24 (21%)
		C2H2 Zn finger	420..440	CDD:275368	1/19 (5%)
		zf-H2C2_2	432..457	CDD:290200	3/24 (13%)
		C2H2 Zn finger	448..468	CDD:275368	9/19 (47%)
		zf-H2C2_2	461..485	CDD:290200	8/23 (35%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		zf-H2C2_2	492..513	CDD:290200	7/28 (25%)
		C2H2 Zn finger	504..524	CDD:275368	8/24 (33%)
		zf-H2C2_2	520..541	CDD:290200	7/20 (35%)
		C2H2 Zn finger	532..552	CDD:275368	8/20 (40%)
		zf-H2C2_2	545..568	CDD:290200	8/23 (35%)
		C2H2 Zn finger	560..580	CDD:275368	7/19 (37%)
		zf-H2C2_2	573..597	CDD:290200	8/29 (28%)
		C2H2 Zn finger	588..608	CDD:275368	5/23 (22%)
		zf-H2C2_2	600..625	CDD:290200	7/28 (25%)
		C2H2 Zn finger	616..636	CDD:275368	5/20 (25%)
		zf-H2C2_2	629..653	CDD:290200	8/24 (33%)
		C2H2 Zn finger	644..664	CDD:275368	5/19 (26%)
		zf-H2C2_2	659..680	CDD:290200	10/20 (50%)
		C2H2 Zn finger	672..692	CDD:275368	9/20 (45%)
		zf-H2C2_2	685..707	CDD:290200	5/22 (23%)
		C2H2 Zn finger	700..720	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910