DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp407

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001028513.2	Gene:	Zfp407 / 240476	MGIID:	2685179	Length:	2246	Species:	Mus musculus

Alignment Length:	807	Identity:	168/807 - (20%)
Similarity:	274/807 - (33%)	Gaps:	263/807 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CM-CEYPAMMGDYIDVHSA-------RGDQLEVTTI------VNQHFPVQISKESDERICGRCWK 60
            || |:|.|:....:..|:|       |...|..:::      ::::..:...:.|
Mouse  1040 CMACDYYAVTRREMTRHAATEKHRMKRQSYLSASSVEAGSSEISKNITIPEEEHS---------- 1094

  Fly    61 IVSDFHTLHEF-VSAAQSS--LQETKVALMEDDPLTQETTSF--------PEIIKLATQEEEGVT 114
                 |...|| :...|||  ||....|   |..:..:.|:.        |:.:.:.|::|...:
Mouse  1095 -----HNSEEFQIHPHQSSGTLQCRNPA---DCSILDDNTNLGMSKVLCAPDSVTVVTEQESNFS 1151

  Fly   115 EPQELGGRNFF----YPEIK---IEEHELD--------TLP---RIEILERSA----NTQENQDQ 157
            |     |.:|.    .|.:|   ::..|:.        :||   :.|.|..||    ..::|:|.
Mouse  1152 E-----GHSFCETLQQPLVKDKSMKPREIVSPNTPSNLSLPGCLQSENLASSAVDCETAKKNRDV 1211

  Fly   158 LEGAARRLRKRLKAED-GSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQL 221
            |:....|   ....|| |.||| |.:|..::::  |.|.....|...:|.::|. .:.|:|.:.|
Mouse  1212 LDAVGDR---STPCEDEGGSVD-DSEEKILDKS--PCPGDPDGGHSAESTSSVV-MKIPREQLDL 1269

  Fly   222 D-------------------------------LKAEELDEFVDEETDPDFSCLVPSDNSSE---- 251
            |                               :.::|..|.:.||..|..:....|::..|
Mouse  1270 DGGGQNKVGCEQTSEDLKDVQANPILENKEILINSQEEAEVILEEDAPTSNGTADSNDVYETIIS 1334

  Fly   252 -DDGG----SDG-FDSD------SDFELDNGKQE--------FAVLPKRTV---VRPKKYKKRTK 293
             ||.|    |.| |||.      .|.||....:|        .:.||.:..   ::.||.:..:.
Mouse  1335 IDDKGQTMYSFGRFDSSIIRIKTEDGELVEQPEEGLTATGGRVSELPLKDCAQGLKKKKVEGGSF 1399

  Fly   294 PAEPKVR-------------MSRELLEQRKKQQEEYDVIIA--KFFT------------------ 325
            ....::|             ::..:..:...:::.:..::.  .|:|
Mouse  1400 GESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQ 1464

  Fly   326 ----------SVLPCAIC--------NLLVHNFTEMQRHHRLTHQVDPGYM-------------- 358
                      :...|..|        ||.:|   ...:|..|..:|:. |:
Mouse  1465 ASVEELPEGGATFKCVKCTEPFDSEQNLFLH---IKGQHEELLREVNK-YIVEDTEQINREREEN 1525

  Fly   359 ---MC--CGRKFTQRKVLA--EHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFS 416
               :|  ||:.......:|  .|:..|.....|||.:|..:........:|.:.|:.   ...:.
Mouse  1526 QGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLG---MREYK 1587

  Fly   417 CDLCSKTFLSKTAIDYHKLNKH---VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIIC- 477
            |.:|...|:.|..::.|.|.||   .|| |.||||..|::.|..:..|.||| .:|..|....|
Mouse  1588 CHVCGVAFVMKKHLNTHLLGKHGVGTPK-ERKFTCHLCDRSFTEKWALNNHM-KLHTGEKPFKCT 1650

  Fly   478 -DKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRC 541
             ..|.....|...:|.|                        .:..||.|..:            |
Mouse  1651 WPTCHYSFLTASAMKDH------------------------YRTHTGEKSFL------------C 1679

  Fly   542 HICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFF 606
            .:|........||.:| ...|..|:.|||..|..|......|..|...||||..|.||.|.....
Mouse  1680 DLCGFAGGTRHALTKH-RRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSN 1743

  Fly   607 CSANMYKHRQRLHRAQYEADK--NQPK 631
            |:.|:.||  .||..::|..|  |.||
Mouse  1744 CAENIRKH--ILHTGKHEGVKMYNCPK 1768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	17/87 (20%)
		FYDLN_acid	<191..268	CDD:302856	26/123 (21%)
		C2H2 Zn finger	330..351	CDD:275368	7/28 (25%)
		C2H2 Zn finger	360..378	CDD:275368	5/21 (24%)
		LIM	361..>400	CDD:295319	9/40 (23%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	22/78 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/22 (23%)
		C2H2 Zn finger	511..532	CDD:275368	3/20 (15%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp407	NP_001028513.2	C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	209..230	CDD:275368
		C2H2 Zn finger	524..552	CDD:275371
		C2H2 Zn finger	553..575	CDD:275371
		C2H2 Zn finger	1407..1436	CDD:275371	0/28 (0%)
		C2H2 Zn finger	1437..1459	CDD:275371	2/21 (10%)
		C2H2 Zn finger	1479..1500	CDD:275371	5/23 (22%)
		C2H2 Zn finger	1530..1552	CDD:275368	5/21 (24%)
		zf-H2C2_2	1548..1569	CDD:290200	6/20 (30%)
		C2H2 Zn finger	1560..1580	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1588..1608	CDD:275368	6/19 (32%)
		COG5048	<1618..1737	CDD:227381	40/156 (26%)
		C2H2 Zn finger	1621..1641	CDD:275368	7/20 (35%)
		zf-H2C2_2	1633..1660	CDD:290200	8/27 (30%)
		C2H2 Zn finger	1649..1671	CDD:275368	5/45 (11%)
		C2H2 Zn finger	1679..1699	CDD:275368	5/20 (25%)
		zf-H2C2_2	1691..1716	CDD:290200	10/25 (40%)
		COG5048	1703..>1758	CDD:227381	21/56 (38%)
		C2H2 Zn finger	1707..1727	CDD:275368	5/19 (26%)
		zf-H2C2_2	1719..1744	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1735..1752	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100