DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp58

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001007576.1	Gene:	Zfp58 / 238693	MGIID:	99205	Length:	489	Species:	Mus musculus

Alignment Length:	494	Identity:	121/494 - (24%)
Similarity:	189/494 - (38%)	Gaps:	125/494 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 DIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDN-GKQEF------- 274
            |:.:|...||.:            ||.|           |.:|...|..|:| ...:|
Mouse     6 DVAIDFSPEERE------------CLEP-----------DQWDLYRDVMLENYSHLDFLGLALSK 47

  Fly   275 ----------------------AVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYD 317
                                  ||.|.:||.:.|.:.        |....:.||.|.::
Mouse    48 PFLVTFLEQRQGPWDVKRQAAAAVHPGKTVNKCKDFS--------KAFFCKSLLTQHQR------ 98

  Fly   318 VIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWN 380
               .:.......|..|....:|.:.:..|.|: |..:..| .|  ||:.|..|..|:.|..||..
Mouse    99 ---IRTGEKAFKCEECGKAFNNRSNLSEHKRI-HTGEKPY-KCEECGKAFRIRSKLSTHQRVHTG 158

  Fly   381 PDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFK 445
            ...:||..|.|:|.:..:|..|:::|..   :..:.|:.|.|.|.:::....|:.| |..|..:|
Mouse   159 EKPYKCEECGKAFNSHSNLSEHKRIHTG---EKPYKCEECGKAFSTRSTYYRHQKN-HTGKKPYK 219

  Fly   446 FTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQ 510
              |.||.|:|.....||.| ..:|..|.:..|::|||.....::|||||.:..::||      .:
Mouse   220 --CEECAKEFSYPSLLKVH-QRIHSAEKSYKCEECGKPFYCPLLLKKHQIIHSAEKP------YK 275

  Fly   511 CQICGAWLKGMTGLKQHMKSIHVESAGEH--RCHICAKVSPNARALRRH---------------- 557
            |..||......:.||:|.: ||   ||:.  :|..|.:...::..|:||
Mouse   276 CAECGKAFHYPSLLKRHQR-IH---AGKKPCKCKDCDRAFYSSAFLKRHQRIHSEENSYKCGECG 336

  Fly   558 ---------IYHN--HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANM 611
                     .||.  |..|:.:||..|.|.|.....|..|...|:||..|.|..|...|:.:.::
Mouse   337 KRFCSFPHLQYHQRFHSGEKPYKCEQCGKTFSTLSYLPWHKLRHSGEKSYKCEKCGKMFYSTLDL 401

  Fly   612 YKHRQRLHRAQYEADKNQPKPPN--ILKISRNASTQNKP 648
            .|| |::|  :|:..:.....||  .|...:...|..||
Mouse   402 KKH-QKIH--EYKCGECHYGFPNYAALTAHQRVHTGEKP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	10/49 (20%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/47 (15%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
Zfp58	NP_001007576.1	KRAB	2..61	CDD:214630	13/77 (17%)
		KRAB	2..41	CDD:279668	12/57 (21%)
		C2H2 Zn finger	80..100	CDD:275368	5/36 (14%)
		COG5048	106..489	CDD:227381	98/354 (28%)
		C2H2 Zn finger	108..128	CDD:275368	5/20 (25%)
		zf-H2C2_2	120..143	CDD:290200	7/24 (29%)
		C2H2 Zn finger	136..156	CDD:275368	7/19 (37%)
		zf-H2C2_2	149..173	CDD:290200	9/23 (39%)
		C2H2 Zn finger	164..184	CDD:275368	6/19 (32%)
		zf-H2C2_2	176..201	CDD:290200	7/27 (26%)
		C2H2 Zn finger	192..212	CDD:275368	6/20 (30%)
		C2H2 Zn finger	220..240	CDD:275368	8/20 (40%)
		C2H2 Zn finger	248..268	CDD:275368	9/19 (47%)
		C2H2 Zn finger	276..296	CDD:275368	6/20 (30%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	332..352	CDD:275368	2/19 (11%)
		zf-H2C2_2	344..369	CDD:290200	9/24 (38%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	6/20 (30%)
		C2H2 Zn finger	412..432	CDD:275368	3/19 (16%)
		zf-H2C2_2	424..449	CDD:290200	4/14 (29%)
		C2H2 Zn finger	440..460	CDD:275368
		C2H2 Zn finger	468..488	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910