DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp454

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001369380.1	Gene:	Zfp454 / 237758	MGIID:	2679253	Length:	536	Species:	Mus musculus

Alignment Length:	592	Identity:	143/592 - (24%)
Similarity:	222/592 - (37%)	Gaps:	138/592 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERS 148
            :|:.:...|.|:..:|.::..|.||||.|    |....:...|.::.:
Mouse     1 MAVSQLPALVQDLVTFKDVAVLFTQEEWG----QLSSAQRALYQDVML----------------- 44

  Fly   149 ANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEE-TAEPAP--------PKKRRGRPRK 204
                ||...|...|..|        ||..|.....:.||| .:|.||        .:...| ||.
Mouse    45 ----ENYSNLVSLAGLL--------GSQPDMFFPLEEVEECVSEEAPEGFVLDAADEPHLG-PRS 96

  Fly   205 SDAAVAP------PQKPKEDIQLDLKAEELDEFVDEETDPDFSCL-------------------- 243
            :..|..|      ....|:.::.|:..:|.|:::.:|.    :|.
Mouse    97 ACEAQVPVTGEITVAMSKKFLKADIPEKESDQWIAKER----ACANLFNWQCQEGQEVKLQQVVL 157

  Fly   244 ----VPSD--------NSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAE 296
                .||.        .||..........|.:.||.....:.|:        :....||..|...
Mouse   158 TQQNTPSKLSEQRVRAESSSPIQSQRSQASKTAFECSECGKAFS--------KSSTLKKHQKLHT 214

  Fly   297 PKVRMSRE--LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMM 359
            .|:..|::  :.|:|.|                  |..|....|..|.: .||:..|..:..| .
Mouse   215 EKLNPSQKSPMKEKRYK------------------CRECGKAFHQSTHL-IHHQRVHTGEKPY-Q 259

  Fly   360 C--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSK 422
            |  ||:.|:....|:.|..:|.....|:|:||.|:|..:.||..|.::|..   :..|.|:||.|
Mouse   260 CKDCGKAFSVSSSLSYHQKIHTGEKPFECNVCGKAFIRNIHLSHHHRMHTG---EKPFQCNLCDK 321

  Fly   423 TFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTK 487
            .|:.:..:..|   :|:...:..:.|:||.|.|........| ..:|..|....|::|||..|..
Mouse   322 AFVCRAHLTKH---QHIHSGKKPYKCNECGKAFNQSTSFLQH-QRIHTGEKPFECNECGKAFRVN 382

  Fly   488 IILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPN 550
            ..|.:||.:...:||      .||..||...:..:...:|.| ||   .||  :||.:|.|...:
Mouse   383 SSLTEHQRIHTGEKP------YQCIECGKAFRDNSSFARHRK-IH---TGEKPYRCGLCEKAFRD 437

  Fly   551 ARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHR 615
            ..||.:| ...|..|:.:.|.:|||||.....|.:|...||.|..|.|..|...|..|.::.:|
Mouse   438 QSALAQH-QRTHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKTCGKAFIRSTHLIQH- 500

  Fly   616 QRLHRAQ 622
            ||:|..:
Mouse   501 QRIHTGE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	21/122 (17%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp454	NP_001369380.1	KRAB	14..67	CDD:214630	17/85 (20%)
		C2H2 Zn finger	193..213	CDD:275368	4/27 (15%)
		COG5048	197..532	CDD:227381	99/358 (28%)
		C2H2 Zn finger	232..252	CDD:275368	6/20 (30%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		C2H2 Zn finger	288..308	CDD:275368	8/19 (42%)
		C2H2 Zn finger	316..336	CDD:275368	7/22 (32%)
		C2H2 Zn finger	344..364	CDD:275368	6/20 (30%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		C2H2 Zn finger	400..420	CDD:275368	5/20 (25%)
		C2H2 Zn finger	428..448	CDD:275368	6/20 (30%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	484..504	CDD:275368	7/20 (35%)
		C2H2 Zn finger	512..532	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910