DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp646

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	1000	Identity:	177/1000 - (17%)
Similarity:	268/1000 - (26%)	Gaps:	444/1000 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSARG---------DQLEVTT-IVNQHFPV----------QISKESD 51
            |.||...:|...|....:..|.|         ::.|.|. ..:.|.|.          |:.:|.:
Mouse   868 CCLCGMIFPGRTGYRRHLRQAHGASAMTEGSEEEEEGTAETASTHSPPLQLSEAELLNQLQREVE 932

  Fly    52 E-------RICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIK----- 104
            .       .|||.|.:...|..:|.....:..||               ..|.:.|..::
Mouse   933 ALDGAGYGHICGCCGQTYDDLGSLERHHQSQSSS---------------NRTENVPSHLEGAGDA 982

  Fly   105 ---LATQEEEG-VTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRL 165
               :|....|| ||...|.||      :||.||....|      :..|...|..:..||...|..
Mouse   983 TEMVADHGFEGTVTSVSEEGG------DIKSEEGVGGT------VADSLCMQAGESFLESHPRPF 1035

  Fly   166 R----KRLKAEDGSSVDKDKDEDGVEETAEPAPP-------------KKRRGRPR--KSDAAVAP 211
            :    .:.....||.|:..|    :.:|.:...|             ...|..||  .|:..:.|
Mouse  1036 QCNQCGKTYRHGGSLVNHRK----IHQTGDFICPVCSRCYPNLAAYRNHLRNHPRCKGSEPQMGP 1096

  Fly   212 ---------PQKPKE---------DIQLDLKAEELDEF--VDEETDPDFSCLVPSDNSSEDDGGS 256
                     ||...|         .:|.:||.|.|:|.  |.||...                |:
Mouse  1097 ISEAGGCSEPQNAAEAGQEQAVIGQLQEELKVEPLEELAGVKEEVWE----------------GT 1145

  Fly   257 DGFDSDSDFELDNGKQEFAVLPKRTVVRP-------KKYKKRTKPAEPKVRMSRELLEQRKKQQE 314
            ...:.:.:.||:.|.|     .:.|..||       :.||.           :..|:..|:..|
Mouse  1146 AVKEEELEQELETGCQ-----TEVTSERPFSCEVCGRTYKH-----------AGSLINHRQSHQ- 1193

  Fly   315 EYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLV 377
                      |....|..|:....|...::.|.|:  ..||....|  ||:.|..||.||.|..|
Mouse  1194 ----------TGHFGCQACSKGFSNLMSLKNHRRI--HADPRQFRCSECGKAFRLRKQLANHQRV 1246

  Fly   378 H--------------------------------------WNPD--HFKCSVCEKSFQNSRHLESH 402
            |                                      .||:  .:.|..|.|::.|...|:.|
Mouse  1247 HAERRRSRGTQKLTREDRPFRCGQCGRTYRHAGSLMNHQCNPEASRYSCPFCFKTYSNRTALKDH 1311

  Fly   403 QQVHMD---------PAVKLTFSCDLCSKTFLSKTAIDYHKLNKH-------------------- 438
            |:||.|         |.......|.||...|..:.:::.| |.:|
Mouse  1312 QRVHSDSQQRRQSGCPQRAAAVRCTLCGCGFSGQGSLEQH-LQEHEDTKLEVASGQGGQHATEGS 1375

  Fly   439 ----------------------------------------------------------------- 438

Mouse  1376 EENLDDWGLEGRSDGTEVLQVEHETKRPGGHSQSPSSPACSGGTESTQQVGKVDGSQGDRGQMNH 1440

  Fly   439 ---------VPKSEFKF-----------------------------------------TCSECNK 453
                     :.|.|.|.                                         .||:|.|
Mouse  1441 NGAWVLQDQLTKPEGKLEDTVSRNPCHLSESQSNGPTLRYRDSWKGADSGSQLQPESHCCSQCGK 1505

  Fly   454 KF--------------------LTERKLKNHMSS---MHDPESTIICDKCGKQMRTKIILKKHQE 495
            .:                    |..::..|.:::   .|.......|..|.|      :.:.|.|
Mouse  1506 AYCQPDGLLNPSINGKDCHICLLCSKEFLNPVTTEIHNHTTAQRFACSNCSK------VCESHSE 1564

  Fly   496 LM---------HS------DKPR-----------PEPELQQ------------------------ 510
            |.         ||      :|.|           |.|...|
Mouse  1565 LATHMKTHAVEHSQMSGQMEKTRGPQAGMAEVGPPGPGKAQEAPSELPGDPEENGVPANGGQGIH 1629

  Fly   511 ------------CQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHE 563
                        |..||...:....|..|.|:   .:.|.:.|.:|.|:.||..:|:.| ...|.
Mouse  1630 FPAAEDKERPFCCAQCGRSYRHAGSLLNHQKA---HTIGLYPCSLCPKLLPNLLSLKNH-SRTHT 1690

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHT-GEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADK 627
            ..:::.|.:|.|||:....|:.|...|. .|..:||.:||..|....:..:|:|: |:.::....
Mouse  1691 DPKRYSCNICGKAFRTAARLQGHGRVHAPQEGPFTCSHCPRRFRHRISFLRHQQQ-HQEEWPVSS 1754

  Fly   628 N--QPKPPNILKISRNASTQNKPKQ 650
            :  ...|....:.|..||..|...|
Mouse  1755 SGASVAPAASREDSSTASLPNPSPQ 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	21/100 (21%)
		FYDLN_acid	<191..268	CDD:302856	20/111 (18%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	9/19 (47%)
		LIM	361..>400	CDD:295319	16/78 (21%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	26/239 (11%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/36 (17%)
		C2H2 Zn finger	477..498	CDD:275368	6/29 (21%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48
		C2H2 Zn finger	69..89	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976		5/34 (15%)
		C2H2 Zn finger	1037..1057	CDD:275368	4/23 (17%)
		C2H2 Zn finger	1064..1084	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1172..1192	CDD:275368	4/30 (13%)
		C2H2 Zn finger	1199..1219	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1268..1285	CDD:275368	0/16 (0%)
		C2H2 Zn finger	1295..1315	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386		3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439		0/40 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489		1/33 (3%)
		C2H2 Zn finger	1500..1518	CDD:275368	4/17 (24%)
		C2H2 Zn finger	1526..1544	CDD:275368	2/17 (12%)
		C2H2 Zn finger	1552..1572	CDD:275368	6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629		5/49 (10%)
		C2H2 Zn finger	1642..1662	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1669..1689	CDD:275368	7/20 (35%)
		zf-H2C2_2	1681..1706	CDD:372612	8/25 (32%)
		C2H2 Zn finger	1697..1717	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1726..1746	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788		7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100