DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF629

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001073886.1	Gene:	ZNF629 / 23361	HGNCID:	29008	Length:	869	Species:	Homo sapiens

Alignment Length:	464	Identity:	124/464 - (26%)
Similarity:	180/464 - (38%)	Gaps:	78/464 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 DKDEDGVEETAEPAPPKKRRGRP-RKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCL 243
            |.......|..|.:|.::..|.. ...|.|.:|..|...::.|:..::          ||.
Human    21 DAHRGAESENEEESPRQESSGEEIIMGDPAQSPESKDSTEMSLERSSQ----------DPS---- 71

  Fly   244 VPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTK--------------- 293
            || .|.....|.|:..  |....||....|  |:|     .|..:.|..:
Human    72 VP-QNPPTPLGHSNPL--DHQIPLDPPAPE--VVP-----TPSDWTKACEASWQWGALTTWNSPP 126

  Fly   294 --PA-EPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDP 355
              || ||.:   |||::.|....|:..:           |..|......::::.||.|:.....|
Human   127 VVPANEPSL---RELVQGRPAGAEKPYI-----------CNECGKSFSQWSKLLRHQRIHTGERP 177

  Fly   356 GYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLC 420
            .....||:.|||...|.:|...|.....:||..|.|.|..|.:|..||:.|..   :..:.|..|
Human   178 NTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFSWSSNLVQHQRTHTG---EKPYKCTEC 239

  Fly   421 SKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMR 485
            .|.|...|.:..|: ..|..:..:|  |.||.:.|.....|..|.:: |..|....|.:|||:..
Human   240 EKAFTQSTNLIKHQ-RSHTGEKPYK--CGECRRAFYRSSDLIQHQAT-HTGEKPYKCPECGKRFG 300

  Fly   486 TKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVS 548
            ....|.|||::...:||      .:|..||......:.|.||.::    ..||  :.|..|.|..
Human   301 QNHNLLKHQKIHAGEKP------YRCTECGKSFIQSSELTQHQRT----HTGEKPYECLECGKSF 355

  Fly   549 PNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYK 613
            .::..|.:| ...|..|..|||.:|.|.|.....|..|..|||||..|.||.|..:|..|:|:..
Human   356 GHSSTLIKH-QRTHLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLIN 419

  Fly   614 HRQRLHRAQ 622
            | ||:||.:
Human   420 H-QRIHRGE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/77 (21%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	21/75 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
ZNF629	NP_001073886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		24/107 (22%)
		COG5048	146..521	CDD:227381	91/312 (29%)
		zf-C2H2	150..172	CDD:278523	5/32 (16%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		zf-C2H2	179..200	CDD:278523	7/20 (35%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	192..216	CDD:290200	7/23 (30%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	220..245	CDD:290200	8/27 (30%)
		C2H2 Zn finger	236..256	CDD:275368	6/20 (30%)
		zf-H2C2_2	248..273	CDD:290200	7/27 (26%)
		C2H2 Zn finger	264..284	CDD:275368	6/20 (30%)
		zf-H2C2_2	276..299	CDD:290200	8/23 (35%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		zf-H2C2_2	304..329	CDD:290200	9/30 (30%)
		C2H2 Zn finger	320..340	CDD:275368	6/23 (26%)
		zf-H2C2_2	332..355	CDD:290200	8/26 (31%)
		C2H2 Zn finger	348..368	CDD:275368	5/20 (25%)
		zf-H2C2_2	361..384	CDD:290200	9/23 (39%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..412	CDD:290200	11/22 (50%)
		zf-C2H2	402..424	CDD:278523	10/22 (45%)
		C2H2 Zn finger	404..424	CDD:275368	9/20 (45%)
		zf-H2C2_2	416..439	CDD:290200	6/13 (46%)
		C2H2 Zn finger	432..452	CDD:275368
		zf-H2C2_2	445..469	CDD:290200
		C2H2 Zn finger	460..480	CDD:275368
		zf-H2C2_2	472..497	CDD:290200
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..651
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..837
		C2H2 Zn finger	844..864	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910