DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF423

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006721234.1	Gene:	ZNF423 / 23090	HGNCID:	16762	Length:	1299	Species:	Homo sapiens

Alignment Length:	651	Identity:	131/651 - (20%)
Similarity:	212/651 - (32%)	Gaps:	214/651 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LEGAARRLRKRLKA-EDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQL 221
            |||.....:|..:| ||.:||...::.:..:|..|              |.::......::|.
Human    43 LEGEPECDQKTSRALEDRNSVTSQEERNEDDEDME--------------DESIYTCDHCQQDF-- 91

  Fly   222 DLKAEELDEFVDE---------ETDPDFSCLVPSDNSSEDDGG-----SDGFDSDSDFELDNGKQ 272
                |.|.:..|.         :.||..| .|.|..||:|...     .||.|      |..|::
Human    92 ----ESLADLTDHRAHRCPGDGDDDPQLS-WVASSPSSKDVASPTQMIGDGCD------LGLGEE 145

  Fly   273 EFAV-LPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLL 336
            |... ||.......|.:          :|:|    ..::.:|...|.:..|       |..|:.|
Human   146 EGGTGLPYPCQFCDKSF----------IRLS----YLKRHEQIHSDKLPFK-------CTYCSRL 189

  Fly   337 VHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHL 399
            ..:.....||.:| |..|..| .|  |...|::...|..|:..|.:...|||:||::.|.::..|
Human   190 FKHKRSRDRHIKL-HTGDKKY-HCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSL 252

  Fly   400 ESHQQVHM----------DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSE-FKFTCSECNK 453
            :||.|.|.          ..|.|..|.||.|..||.....::.|.|.:|...|| ....|..|.:
Human   253 QSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQLSEKADLQCIHCPE 317

  Fly   454 KFLTERKLKNHMSSMH------------------------------------------------- 469
            .|:.|..|..|:...|
Human   318 VFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASM 382

  Fly   470 ---------------DPESTI---------------------ICDKCGKQ-MRTKIILKKHQELM 497
                           .|:||:                     .|..|.|: ..:..:|:.|.:.:
Human   383 SSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFNSLAVLEIHLKTI 447

  Fly   498 HSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESA---------GEHRCHICAKVSPNARA 553
            |:|||:   :...||||...:..:..|.:|::.:|...|         ....|:.|.::..:..:
Human   448 HADKPQ---QSHTCQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNISAFHCNYCPEMFADINS 509

  Fly   554 LRRHIYHNH--------ECERKFKCTMCEKAFKRPQELKEHTS------------------THTG 592
            |:.||..:|        :....|.|..|...|.....|.||..                  |.:.
Human   510 LQEHIRVSHCGPNANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAKLESPVVQPTQSF 574

  Fly   593 EVLYTCPNCPMT--FFCSANMYKHRQRLHR----AQYEADKNQPKPPNILKISRNASTQNKPKQE 651
            ..:|:||.|..:  |.....:.||.:..|:    |..:..|.:..|     :|.:....:..:|.
Human   575 MEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSP-----VSSDVEVSSPKRQR 634

  Fly   652 I 652
            :
Human   635 L 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	17/90 (19%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	25/86 (29%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/21 (24%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/37 (16%)
		C2H2 Zn finger	598..619	CDD:275368	6/22 (27%)
ZNF423	XP_006721234.1	C2H2 Zn finger	155..175	CDD:275368	4/33 (12%)
		C2H2 Zn finger	183..203	CDD:275368	6/20 (30%)
		COG5048	209..610	CDD:227381	80/404 (20%)
		C2H2 Zn finger	211..231	CDD:275368	5/19 (26%)
		C2H2 Zn finger	239..259	CDD:275368	8/19 (42%)
		C2H2 Zn finger	280..299	CDD:275368	6/18 (33%)
		C2H2 Zn finger	426..447	CDD:275368	5/20 (25%)
		C2H2 Zn finger	458..479	CDD:275368	6/20 (30%)
		C2H2 Zn finger	497..516	CDD:275368	5/18 (28%)
		C2H2 Zn finger	679..699	CDD:275368
		C2H2 Zn finger	709..730	CDD:275368
		C2H2 Zn finger	737..758	CDD:275368
		C2H2 Zn finger	767..788	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	824..842	CDD:275368
		C2H2 Zn finger	903..924	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1215..1235	CDD:275368
		C2H2 Zn finger	1246..1267	CDD:275368
		C2H2 Zn finger	1276..1292	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910