DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp64

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_033590.2	Gene:	Zfp64 / 22722	MGIID:	107342	Length:	676	Species:	Mus musculus

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	171/478 - (35%)	Gaps:	100/478 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNG 270
            ||.||..|...:.....:.|....:||.|||:|.......:.:|.......    |..:|..::|
Mouse    44 DAFVAHKQSGCQLTTTPVTAPSTVQFVAEETEPATQTTTTTISSETQTITV----SAPEFVFEHG 104

  Fly   271 KQEFAVLPKR-------TVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVL 328
            .|.:  ||..       ||:......:..||..|..        |::                 |
Mouse   105 YQTY--LPTESTDNQTATVISLPTKSRTKKPTAPPA--------QKR-----------------L 142

  Fly   329 PCAI--CNL-LVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCE 390
            .|..  |.. ..:...:|:||.::.....|.....||:.|:::..|..|:..|.....:||..|:
Mouse   143 GCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCD 207

  Fly   391 KSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKF 455
            .:..:|..|..|.::|.|   :..|.|.:|.....:.:.:..| |..|.  .:..|.|..|:.||
Mouse   208 YAAADSSSLNKHLRIHSD---ERPFKCQICPYASRNSSQLTVH-LRSHT--GDAPFQCWLCSAKF 266

  Fly   456 LTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKG 520
            .....||.|| .:|..|....|:.|..:...|..||.|..:.||......|   .|...|   ..
Mouse   267 KISSDLKRHM-RVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCP---HCDFLG---DS 324

  Fly   521 MTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKE 585
            .:.|::|.: :| :|....:|..|:....:..|||.| ...|..||.|||:.|....|:|..|.:
Mouse   325 KSTLRKHSR-LH-QSEHPEKCPECSYSCSSKAALRVH-ERIHCTERPFKCSYCSFDTKQPSNLSK 386

  Fly   586 HTSTHTGEVL--------------------------YTCPNCPMTFFCSANMYKHRQRLHRAQYE 624
            |......::|                          :.|..|..:|....::..|:::  .::|.
Mouse   387 HMKKFHADMLKNEAPEKKESGRQSSRQVARLDAKKTFHCDICDASFMREDSLRSHKRQ--HSEYH 449

  Fly   625 ADKN--------------QPKPP 633
            : ||              ||..|
Mouse   450 S-KNSDVTVVQLHLEPSKQPAAP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	15/61 (25%)
		C2H2 Zn finger	330..351	CDD:275368	5/23 (22%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
Zfp64	NP_033590.2	COG5048	<149..448	CDD:227381	73/316 (23%)
		zf-H2C2_2	159..184	CDD:290200	7/24 (29%)
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		zf-H2C2_2	188..209	CDD:290200	6/20 (30%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		zf-H2C2_2	215..237	CDD:290200	7/24 (29%)
		C2H2 Zn finger	231..251	CDD:275368	4/20 (20%)
		C2H2 Zn finger	259..279	CDD:275368	8/20 (40%)
		zf-H2C2_2	271..295	CDD:290200	8/24 (33%)
		C2H2 Zn finger	287..306	CDD:275368	6/18 (33%)
		C2H2 Zn finger	343..363	CDD:275368	6/20 (30%)
		zf-H2C2_2	355..380	CDD:290200	11/25 (44%)
		C2H2 Zn finger	371..389	CDD:275368	6/17 (35%)
		zf-C2H2_6	422..448	CDD:290623	4/27 (15%)
		C2H2 Zn finger	425..445	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030