DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zscan2

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	655	Identity:	162/655 - (24%)
Similarity:	231/655 - (35%)	Gaps:	204/655 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EYPAM---MGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSA 74
            |.||:   :...:.|.....:|.||||::         .|.|      .|
Mouse     4 EVPAVSTPLSPLVQVPQEEDEQAEVTTMI---------LEDD------AW--------------- 38

  Fly    75 AQSSLQETKVALMEDDPLTQETTSFPEII-KLATQEEEGVTEPQ-------ELGGRNFFYPEIKI 131
                :||  ..|.||.|   |:..||:.. |.:.|||:....||       || .|.:..||:..
Mouse    39 ----VQE--AVLQEDGP---ESEPFPQSAGKGSPQEEDAAEGPQGALVRFREL-CRRWLRPEVHT 93

  Fly   132 EEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPK 196
            :|..|..|||    |..|..||:
Mouse    94 KEQMLTVLPR----EIQAWLQEH------------------------------------------ 112

  Fly   197 KRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSED--------- 252
                ||..|:.|||    ..||:....:..:.:  :..|.         .:||:||
Mouse   113 ----RPESSEEAVA----LVEDLTQTFRHSDFE--IQSEN---------GENSNEDMFEGVESHG 158

  Fly   253 -----DGGSDG--FDSDSDFELD---NGKQEFAVLPKRTVVRPKKYKKRTKPAE-PKVRMS--RE 304
                 .||..|  .|.|||||.|   .|.|..|                  |.| |:|..|  ||
Mouse   159 MFLNISGGEGGQQSDGDSDFERDCGSGGAQGHA------------------PGEDPRVVPSEGRE 205

  Fly   305 L-----LEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQ---VDPGYMMC- 360
            :     |:.....::.|:            |..|..     |..::.|.:||:   ....|..|
Mouse   206 VGQLIGLQGTYLGEKPYE------------CPQCGK-----TFSRKSHLITHERTHTGEKYYKCD 253

  Fly   361 -CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTF 424
             ||:.|:.....:.|...|.....:||..|.|||..|.:|.:||::|..   :..|.|..|.|:|
Mouse   254 ECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTG---EKPFQCAECGKSF 315

  Fly   425 LSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKII 489
            .....:..|: ..|.  .|..::|.||.|.|.....|..| ..:|..|....|.:||:.......
Mouse   316 SRSPNLIAHQ-RTHT--GEKPYSCPECGKSFGNRSSLNTH-QGIHTGEKPYACKECGESFSYNSN 376

  Fly   490 LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNAR 552
            |.:||.:...:||      .:|..||......:.|..|.::    ..||  ::|..|.|....:.
Mouse   377 LIRHQRIHTGEKP------YKCTECGQKFSQSSALITHRRT----HTGEKPYQCGECGKNFSRSS 431

  Fly   553 ALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQR 617
            .|..| ...|..|:.:||.:|.|:|.:...|..|..|||||..|.|..|..:|..|:|:.|| ||
Mouse   432 NLATH-RRTHLVEKPYKCGLCGKSFSQSSSLIAHQGTHTGEKPYECLTCGESFSWSSNLIKH-QR 494

  Fly   618 LHRAQ 622
            .|..:
Mouse   495 THTGE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	12/70 (17%)
		FYDLN_acid	<191..268	CDD:302856	22/92 (24%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73		11/33 (33%)
		SCAN	69..131	CDD:396558	24/116 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		17/55 (31%)
		COG5048	220..600	CDD:227381	87/316 (28%)
		C2H2 Zn finger	224..244	CDD:275368	6/24 (25%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		C2H2 Zn finger	308..328	CDD:275368	5/20 (25%)
		C2H2 Zn finger	336..356	CDD:275368	7/20 (35%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	5/23 (22%)
		C2H2 Zn finger	420..440	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	9/20 (45%)
		C2H2 Zn finger	504..524	CDD:275368
		C2H2 Zn finger	532..552	CDD:275368
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910