DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp521

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	630	Identity:	133/630 - (21%)
Similarity:	211/630 - (33%)	Gaps:	217/630 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KAEDGSSVD-KDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVD 233
            |.|||.:|| |.:.||| ||..|.|        ....|:.:...:...:..:..:...:|.:.||
Mouse    22 KIEDGEAVDCKKRPEDG-EELEEDA--------VHSCDSCLQVFESLSDITEHKIHQCQLTDGVD 77

  Fly   234 EETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAV-LPKRTVVRPKKYKKRTKPAEP 297
            .|.||  ||..|:.:.|..|..|.......||    |::|... ||.......|.:.:
Mouse    78 VEDDP--SCSWPASSPSSKDQTSPSHGEGCDF----GEEEGGPGLPYPCQFCDKSFSR------- 129

  Fly   298 KVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC 360
                    |...|..::.:        :..||  |..|:.|..:.....||.:| |..|..| .|
Mouse   130 --------LSYLKHHEQSH--------SDKLPFKCTYCSRLFKHKRSRDRHIKL-HTGDKKY-HC 176

  Fly   361 --CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH-------------MDPA 410
              |...|::...|..|:..|.:...:||:||.:.|.:|..|..|.|||             .|..
Mouse   177 SECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWK 241

  Fly   411 VKLTFSCDLCSKTF-----LSKTAIDYH-------------------------KLNKHVPK---S 442
            :|.|..|..|.:.|     |.|...:.|                         .|..|:.:   .
Mouse   242 MKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCMYCHELFVEETSLMNHIEQVHGG 306

  Fly   443 EFKFTCSECNKKFLTERKLKNHMSSMHDPES---------------------------------- 473
            |.|.:||.|::.|||..:|.:||.|...|||
Mouse   307 EKKNSCSICSESFLTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMV 371

  Fly   474 --------------------------------TIICDKCGKQMRTKI-ILKKHQELMHSDKPRPE 505
                                            |..|..|.||:.:.: :|:.|.:.||.|||.
Mouse   372 EAAPPIPKSRGRKRAAQQTSDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPE-- 434

  Fly   506 PELQQCQICGAWLKGMTGLKQHMKSIH-VESAG---------EHRCHICAKVSPNARALRRHIYH 560
             :...||.|...|..:..|.:|:|.:| .:..|         .::|:.|::|..:...|:.||
Mouse   435 -QAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHI-- 496

  Fly   561 NHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEA 625
                       .|...|..|.....:.        :.||:|.|.|...:::.:|.:::| .....
Mouse   497 -----------RCSHGFANPAAKDSNA--------FFCPHCYMGFLTDSSLEEHIRQVH-CDLSG 541

  Fly   626 DK------NQPKPP-----------------NILKISRNASTQNK 647
            .:      ..||.|                 ::||::::....:|
Mouse   542 SRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	17/76 (22%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	28/121 (23%)
		C2H2 Zn finger	417..438	CDD:275368	7/50 (14%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/21 (29%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	3/19 (16%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		10/32 (31%)
		COG5048	<83..236	CDD:227381	43/181 (24%)
		C2H2 Zn finger	120..140	CDD:275368	3/34 (9%)
		C2H2 Zn finger	148..168	CDD:275368	6/20 (30%)
		C2H2 Zn finger	176..196	CDD:275368	5/19 (26%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	248..265	CDD:275368	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398		0/40 (0%)
		C2H2 Zn finger	407..428	CDD:275368	6/20 (30%)
		C2H2 Zn finger	439..460	CDD:275368	7/20 (35%)
		C2H2 Zn finger	479..498	CDD:275368	6/31 (19%)
		C2H2 Zn finger	636..656	CDD:275368
		C2H2 Zn finger	666..686	CDD:275368
		C2H2 Zn finger	696..713	CDD:275368
		C2H2 Zn finger	724..745	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	785..805	CDD:275368
		C2H2 Zn finger	811..829	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010