DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF485

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	427	Identity:	105/427 - (24%)
Similarity:	162/427 - (37%)	Gaps:	65/427 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 KPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLP 278
            |||...||:..||...|..:          .||...:.:|   ..|::... .|.....|.:||.
Human    56 KPKLITQLEQGAEPWTEVRE----------APSGTHAVED---YWFETKMS-ALKQSTSEASVLG 106

  Fly   279 KRTVVRPKKYKKRTKPAEPKVRMSREL-LEQRKKQQEEYDV-IIAKFF-------------TSVL 328
            :||               ..|.|.:.| .|.|...::.|.. ...|.|             ||..
Human   107 ERT---------------KSVMMEKGLDWEGRSSTEKNYKCKECGKVFKYNSSFISHQRNHTSEK 156

  Fly   329 P--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEK 391
            |  |..|.:...|.:.:..||::.....|...:.||:...:......|..:|......||..|.|
Human   157 PHKCKECGIAFMNSSSLLNHHKVHAGKQPYRCIECGKFLKKHSTFINHQRIHSREKPHKCIECGK 221

  Fly   392 SFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL 456
            :|:.:..|.|||::|..   :..:.|:.|.|.|....|:..|   :.:...|..|.|::|.:.|.
Human   222 TFRKNSILLSHQRIHTG---QKPYKCNDCGKAFAQNAALTRH---ERIHSGEKPFKCNKCGRAFR 280

  Fly   457 TERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGM 521
            ....:..| ..:|..|....|::|||..|....|..||.:...:||      ..|..||...:..
Human   281 DNSTVLEH-QKIHTGEKPYQCNECGKAFRKSSTLISHQRMHTGEKP------YHCSKCGKSFRYS 338

  Fly   522 TGLKQHMKSIHVESAGE-HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKE 585
            :....|.|:   .|..: ::|..|.|....:..|..| ...|..|:.:.|..|.|||:....|.|
Human   339 SSFAGHQKT---HSGNKPYQCRDCGKAFTKSSTLTGH-QRIHTGEKPYHCKKCGKAFRHSSGLVE 399

  Fly   586 HTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            |...||||..|.|..|...|..|:.:.:|: ::|..:
Human   400 HQRLHTGEKPYKCNECGKAFPRSSALKQHK-KIHNKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	12/53 (23%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	3/17 (18%)
		LIM	361..>400	CDD:295319	9/38 (24%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	3/16 (19%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630	7/14 (50%)
		KRAB	11..50	CDD:279668
		COG5048	<124..361	CDD:227381	58/252 (23%)
		C2H2 Zn finger	132..152	CDD:275368	2/19 (11%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		C2H2 Zn finger	188..208	CDD:275368	3/19 (16%)
		C2H2 Zn finger	216..236	CDD:275368	8/19 (42%)
		zf-H2C2_2	229..253	CDD:290200	9/26 (35%)
		C2H2 Zn finger	244..264	CDD:275368	6/22 (27%)
		zf-H2C2_2	256..279	CDD:290200	6/25 (24%)
		C2H2 Zn finger	272..292	CDD:275368	4/20 (20%)
		zf-H2C2_2	287..307	CDD:290200	7/20 (35%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..337	CDD:290200	8/29 (28%)
		C2H2 Zn finger	328..348	CDD:275368	5/22 (23%)
		C2H2 Zn finger	356..376	CDD:275368	5/20 (25%)
		zf-H2C2_2	372..393	CDD:290200	8/21 (38%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..419	CDD:290200	10/21 (48%)
		C2H2 Zn finger	412..432	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910