DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp180

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001038951.1	Gene:	Zfp180 / 210135	MGIID:	1923701	Length:	655	Species:	Mus musculus

Alignment Length:	651	Identity:	151/651 - (23%)
Similarity:	230/651 - (35%)	Gaps:	183/651 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DPLTQETTSFPEIIKLATQE--EEGVTEPQELGGRNFFYPE--IKIEEH-ELDTLPRIEILERSA 149
            |.:.||:|.|    |:.|.:  |||    |.:.......||  :.:|.| :|..||.:...|.:.
Mouse    38 DIMPQESTDF----KIVTVDLTEEG----QSMWNNAQRTPEKTVILEGHRDLWDLPAVHGTEGAT 94

  Fly   150 NTQE--NQD-----QLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDA 207
            ..|.  |::     :|||:||                  |:..:....|....|::.|:
Mouse    95 AKQTIFNEEPSHGLKLEGSAR------------------DDPWLSTCEEVRDCKEQSGK------ 135

  Fly   208 AVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCL---------VP------------------ 245
               .|.| :|::.....:....:.|....|||.|||         :|
Mouse   136 ---QPNK-QEEVAFTQGSAGSPDTVYRGHDPDRSCLSTSRPSFPMIPLRNHFHKQASHVKKLHGD 196

  Fly   246 ---------SDNSS--EDD------------------GGSDGFDSDSDFELD------------- 268
                     ||:|.  |||                  .|.:.::.:...:..
Mouse   197 VVASSHQKISDSSDLLEDDTAGAVPQSIRPSQFVSSPQGEEAYELNGHVQASGRGAPRNLNEKVP 261

  Fly   269 ---------------------NGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQ 312
                                 .|:||.       :|:..:.|.:|.|: |.:..|.....:.|:.
Mouse   262 LEGKTFGFKGRGQVLNHSVVLGGQQEL-------LVKEGQDKCKTAPS-PSLPQSLRNYSEEKRF 318

  Fly   313 QEEY--------DVIIA--KFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKF 365
            :.:|        ..:||  :..|...|  |.:|.......:.:..|.|:.....|.....||:.|
Mouse   319 ECKYCGKSFSWSSHLIAHQRTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSF 383

  Fly   366 TQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAI 430
            |||.||..|...|.....::|:.|.|||:.|..|.:||:.|..   :..:.|..|.|:|     |
Mouse   384 TQRYVLVVHQRTHTGERPYECTQCGKSFRQSYKLIAHQRTHTG---EKPYECTQCGKSF-----I 440

  Fly   431 DYHKLNKH--VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH 493
            ..:||..|  :...|..:.||.|.|.|....||..|..: |..|....|:.|||.......|..|
Mouse   441 QSYKLIAHQKIHSGEKPYECSHCGKSFSQSYKLVAHQRT-HTGEKPFECNHCGKSFSWSSQLVSH 504

  Fly   494 QELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRR 556
            |.....:||      .:|..||......:.|..|.::    ..||  ::|..|.|....:..|..
Mouse   505 QRTHTGEKP------YECNECGKSFNRSSHLVMHQRT----HTGEKPYQCKQCGKSFSQSYVLVV 559

  Fly   557 HIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRA 621
            | ...|..|:.::|..|.|.|::.....:|..|||||..|.|..|..||..||.:..| ||.|..
Mouse   560 H-QRTHTGEKPYECGQCGKTFRQSSCFTQHQRTHTGEKPYECNQCGKTFSLSARLIVH-QRTHTG 622

  Fly   622 Q 622
            :
Mouse   623 E 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	21/132 (16%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	9/17 (53%)
		LIM	361..>400	CDD:295319	16/38 (42%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	25/77 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
Zfp180	NP_001038951.1	COG5048	297..650	CDD:227381	98/349 (28%)
		zf-C2H2	318..340	CDD:278523	3/21 (14%)
		C2H2 Zn finger	320..340	CDD:275368	3/19 (16%)
		zf-H2C2_2	332..357	CDD:290200	6/24 (25%)
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		zf-H2C2_2	360..385	CDD:290200	6/24 (25%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..413	CDD:290200	8/23 (35%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		zf-H2C2_2	420..441	CDD:290200	7/28 (25%)
		C2H2 Zn finger	432..452	CDD:275368	8/24 (33%)
		zf-H2C2_2	448..469	CDD:290200	7/20 (35%)
		C2H2 Zn finger	460..480	CDD:275368	8/20 (40%)
		zf-H2C2_2	473..496	CDD:290200	8/23 (35%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		zf-H2C2_2	501..525	CDD:290200	8/29 (28%)
		C2H2 Zn finger	516..536	CDD:275368	5/23 (22%)
		zf-H2C2_2	528..553	CDD:290200	7/28 (25%)
		C2H2 Zn finger	544..564	CDD:275368	5/20 (25%)
		zf-H2C2_2	557..581	CDD:290200	8/24 (33%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	587..608	CDD:290200	10/20 (50%)
		C2H2 Zn finger	600..620	CDD:275368	9/20 (45%)
		zf-H2C2_2	613..637	CDD:290200	4/12 (33%)
		C2H2 Zn finger	628..648	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910