DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF449

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_689908.3	Gene:	ZNF449 / 203523	HGNCID:	21039	Length:	518	Species:	Homo sapiens

Alignment Length:	614	Identity:	125/614 - (20%)
Similarity:	191/614 - (31%)	Gaps:	219/614 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETT 97
            |:.|.|.:|.|     |:.||:......:..:.....:.|......|:|.........|.|....
Human    85 EIETWVREHCP-----ENRERVVSLIEDLQRELEIPEQQVDMHDMLLEELAPVGTAHIPPTMHLE 144

  Fly    98 SFPEIIKLATQEEEGVTE-------PQELG------GRNFF---YPEIKIEEHELDTLPRIEI-- 144
            | |.:..:...:|..|.|       |.||.      .:||.   ||           ||::::
Human   145 S-PALQVMGPAQEAPVAEAWIPQAGPPELNYGATGECQNFLDPGYP-----------LPKLDMNF 197

  Fly   145 -LERSAN--TQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVE----ETAEP----APPKKR 198
             ||....  .:|.||     ::.:::.|.::.|..:..:.:||..:    ||..|    ......
Human   198 SLENREEPWVKELQD-----SKEMKQLLDSKIGFEIGIENEEDTSKQKKMETMYPFIVTLEGNAL 257

  Fly   199 RGRPRKSDAAVAPPQ--KPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDS 261
            :|...:.|......|  .|.||:|.||.     :.||:: :|... ..|.:::.|:.
Human   258 QGPILQKDYVQLENQWETPPEDLQTDLA-----KLVDQQ-NPTLG-ETPENSNLEEP-------- 307

  Fly   262 DSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTS 326
                                 :.||.:||::...:|
Human   308 ---------------------LNPKPHKKKSPGEKP----------------------------- 322

  Fly   327 VLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEK 391
                                ||...         ||:.|.::..|..|..:|...:..||..|.|
Human   323 --------------------HRCPQ---------CGKCFARKSQLTGHQRIHSGEEPHKCPECGK 358

  Fly   392 SFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL 456
            .|..|..|..||::|                                  ..|..:.|:.|.|:|.
Human   359 RFLRSSDLYRHQRLH----------------------------------TGERPYECTVCKKRFT 389

  Fly   457 TERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGM 521
            ....|..|..: |..|.|..|.:|||.......||:|.:....:||
Human   390 RRSHLIGHQRT-HSEEETYKCLECGKSFCHGSSLKRHLKTHTGEKP------------------- 434

  Fly   522 TGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEH 586
                             ||||.|.|......||..| ...|..||.|||..|.|:|::...|..|
Human   435 -----------------HRCHNCGKSFSRLTALTLH-QRTHTEERPFKCNYCGKSFRQRPSLVIH 481

  Fly   587 TSTHTGEVLYTCPNCPMTFFCSANMYKHR 615
            ...||||..|.|.:|..:|...|.:..|:
Human   482 LRIHTGEKPYKCTHCSKSFRQRAGLIMHQ 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	10/47 (21%)
		FYDLN_acid	<191..268	CDD:302856	15/82 (18%)
		C2H2 Zn finger	330..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	14/75 (19%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	0/20 (0%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/18 (28%)
ZNF449	NP_689908.3	SCAN	27..134	CDD:322011	11/53 (21%)
		SFP1	<235..402	CDD:227516	48/295 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..325		9/111 (8%)
		COG5048	<321..483	CDD:227381	58/291 (20%)
		C2H2 Zn finger	325..345	CDD:275368	5/28 (18%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		C2H2 Zn finger	381..401	CDD:275368	6/20 (30%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	7/20 (35%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		zf-H2C2_2	477..502	CDD:316026	10/24 (42%)
		C2H2 Zn finger	493..513	CDD:275368	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910