DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF626

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001070143.1	Gene:	ZNF626 / 199777	HGNCID:	30461	Length:	528	Species:	Homo sapiens

Alignment Length:	550	Identity:	125/550 - (22%)
Similarity:	205/550 - (37%)	Gaps:	128/550 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 TTSFPEII--------KLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQ 152
            |.|.|::|        .|..:..|.:.:|..:  .:.|..::..|:...|:..:: :|.|....:
Human    46 TVSKPDLITCLEQGRKPLTMKRNEMIAKPSVM--CSHFAQDLWPEQSMKDSFQKV-VLRRYEKCE 107

  Fly   153 ENQDQLEGAARRLRKRLKAEDGSSVDKDK-DEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPK 216
            .:..||:...            .|||:.| .::|..|..:                  .....|:
Human   108 HDNLQLKKGC------------ISVDECKVHKEGYNELNQ------------------CLTTTPR 142

  Fly   217 EDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFE-LDNGK--QEFAVLP 278
            :..|.|...:.|.:|             |:.|     |...|......|: ::.||  ::|:
Human   143 KICQCDKYVKVLHQF-------------PNSN-----GQKRGHTGKKPFKYIECGKAFKQFS--- 186

  Fly   279 KRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEM 343
              |:...||.....||.:                                 |..|....::...:
Human   187 --TLTTHKKIHTGGKPYK---------------------------------CEECGKAFNHSCSL 216

  Fly   344 QRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH 406
            .||.:: |..:..| .|  ||:.|.....|..|...|.....:||..|.|:|.:|..|..|:.:|
Human   217 TRHKKI-HTGEKPY-KCEECGKAFKHSSTLTTHKRNHTGEKPYKCDKCGKAFMSSSTLSKHEIIH 279

  Fly   407 MDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDP 471
            .:   |..:.|:.|.|.|...:.:..||:   :...|..:.|.||:|.|.....|..| ..:|..
Human   280 TE---KKPYKCEECGKAFNRSSTLTTHKI---IHTGEKPYKCEECDKAFKYSYTLTTH-KRIHTE 337

  Fly   472 ESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESA 536
            :....|::|||..:....|..|:.:...:||      .:|:.||...|..:.|..| |.||   .
Human   338 DKPYKCEECGKAFKYSSTLTTHKRIHTGEKP------YKCEECGKAFKRSSDLTTH-KIIH---T 392

  Fly   537 GE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCP 599
            ||  ::|..|.|....:..|..| ...|..||.:||..|.|||.:...|..|...||||..|.|.
Human   393 GEKPYKCEECGKAFKYSSNLTTH-KKIHTGERPYKCEECGKAFNQSSILTTHRRIHTGEKFYKCE 456

  Fly   600 NCPMTFFCSANMYKHRQRLHRAQ--YEADK 627
            .|...|.||:|:..|: ::|..:  |:.::
Human   457 ECGKAFKCSSNLTTHK-KIHTGERPYKCEE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	10/77 (13%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	21/75 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF626	NP_001070143.1	KRAB	4..62	CDD:214630	4/15 (27%)
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	177..195	CDD:275368	6/22 (27%)
		zf-H2C2_2	188..212	CDD:290200	6/56 (11%)
		COG5048	199..520	CDD:227381	89/340 (26%)
		C2H2 Zn finger	203..223	CDD:275368	4/20 (20%)
		zf-H2C2_2	215..240	CDD:290200	8/26 (31%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		zf-H2C2_2	244..266	CDD:290200	7/21 (33%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..296	CDD:290200	8/26 (31%)
		C2H2 Zn finger	287..307	CDD:275368	6/22 (27%)
		zf-H2C2_2	300..324	CDD:290200	8/26 (31%)
		C2H2 Zn finger	315..335	CDD:275368	7/20 (35%)
		zf-H2C2_2	328..352	CDD:290200	7/24 (29%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		zf-H2C2_2	356..380	CDD:290200	7/29 (24%)
		C2H2 Zn finger	371..391	CDD:275368	7/20 (35%)
		zf-H2C2_2	383..408	CDD:290200	10/28 (36%)
		C2H2 Zn finger	399..419	CDD:275368	5/20 (25%)
		zf-H2C2_2	411..436	CDD:290200	11/25 (44%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		zf-H2C2_2	440..464	CDD:290200	10/23 (43%)
		C2H2 Zn finger	455..475	CDD:275368	7/20 (35%)
		zf-H2C2_2	467..492	CDD:290200	4/19 (21%)
		C2H2 Zn finger	483..502	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910