DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF778

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001188336.1	Gene:	ZNF778 / 197320	HGNCID:	26479	Length:	757	Species:	Homo sapiens

Alignment Length:	324	Identity:	93/324 - (28%)
Similarity:	134/324 - (41%)	Gaps:	40/324 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 VIIAKFF-------------TSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKF 365
            |:..|:|             |.:.|  |:.|.........:.||.| ||..:..| .|  ||:.|
Human   396 VVCGKYFRNSSCLNNHVRIHTGIKPYTCSYCGKAFTVRCGLTRHVR-THTGEKPY-TCKDCGKAF 458

  Fly   366 TQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAI 430
            .....|.|||..|.....::|..|.|||..|..|..|.::|..   :..:.|..|.|.|..::.:
Human   459 CTSSGLTEHVRTHTGEKPYECKDCGKSFTVSSSLTEHARIHTG---EKPYECKQCGKAFTGRSGL 520

  Fly   431 DYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQE 495
            ..| :..|.  .|..:.|.:|.|.:.....|..|:.: |..|...||..|.|..|....|.||.:
Human   521 TKH-MRTHT--GEKPYECKDCGKAYNRVYLLNEHVKT-HTEEKPFICTVCRKSFRNSSCLNKHIQ 581

  Fly   496 LMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHI 558
            :....||      .:|:.||......:.|.:|:::    ..||  :.|.:|.|....:..|..||
Human   582 IHTGIKP------YECKDCGKTFTVSSSLTEHIRT----HTGEKPYECKVCGKAFTTSSHLIVHI 636

  Fly   559 YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
             ..|..|:.:.|..|.|||.....|.||..|||||..|.|..|...|..|::::|| .|:|..|
Human   637 -RTHTGEKPYICKECGKAFASSSHLIEHRRTHTGEKPYICNECGKAFRASSHLHKH-GRIHTGQ 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF778	NP_001188336.1	KRAB	42..100	CDD:214630
		C2H2 Zn finger	283..303	CDD:275368
		C2H2 Zn finger	311..331	CDD:275368
		C2H2 Zn finger	339..358	CDD:275368
		C2H2 Zn finger	367..387	CDD:275368
		COG5048	380..747	CDD:227381	93/324 (29%)
		C2H2 Zn finger	395..415	CDD:275368	3/18 (17%)
		C2H2 Zn finger	423..443	CDD:275368	5/20 (25%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		C2H2 Zn finger	507..527	CDD:275368	5/20 (25%)
		C2H2 Zn finger	535..555	CDD:275368	5/20 (25%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
		C2H2 Zn finger	591..611	CDD:275368	5/23 (22%)
		C2H2 Zn finger	619..639	CDD:275368	6/20 (30%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		C2H2 Zn finger	675..695	CDD:275368	7/20 (35%)
		C2H2 Zn finger	703..722	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910