DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf-782

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	112/465 - (24%)
Similarity:	169/465 - (36%)	Gaps:	117/465 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EDIQL-DLKAEELDEFVD------EETDPDFSCLVPSDNSSE--DDGGSDGFDSDSDFELDNGKQ 272
            :||.: |.:.||.:|:.|      ||.|.:...|..||::|.  ..|...|..|      .||..
Worm    17 DDIHMKDPEEEEFEEYEDELLEEEEEFDEELEELENSDSASSLVSAGSPHGSSS------SNGSH 75

  Fly   273 EFAVLPKRTVVRPKK--YKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNL 335
            ..:  |...|..|.:  ....:...:|:.|..                           |.:|..
Worm    76 GSS--PPLQVQSPSQGSGSSGSPTGQPEKRHI---------------------------CTVCGK 111

  Fly   336 LVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSF----- 393
            ....|:.::.|.| :|..:..| .|  |.:.|.|:..|..|...|.....:||..|||:|
Worm   112 GFSYFSILESHKR-SHTGEKPY-NCHFCQKTFAQKATLQVHERTHTGERPYKCRYCEKTFAQYGT 174

  Fly   394 ----QNSRH--------------------LESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHK 434
                :.|.|                    |.:|::.|.|.    ||.||.|.|||..|..:..|.
Worm   175 KTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTHGDK----TFRCDFCPKTFALKNYLKLHV 235

  Fly   435 LNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHS 499
            ...| .::|.|..|..|||.|.....|:.|:.: |..|...:|..|.|...::..|:.|:.....
Worm   236 KQVH-EQNERKHVCVYCNKGFAYAGSLQVHVRT-HTGERPYVCKFCPKAFASQGNLQSHERTHTG 298

  Fly   500 DKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHI------ 558
            ::|      ..||.|     ..|.:::...:.| ||.     |:..|.|.|..:....|
Worm   299 ERP------YSCQFC-----QRTFIQKSQLTAH-EST-----HLTQKHSVNPDSTTADILPVAGS 346

  Fly   559 YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNC--PMTFFCSANMYKHRQRLHRA 621
            ..:|:....::||.|.|.:.....|..|...||.:..|:|..|  |.:...|.|       :|:.
Worm   347 VTDHQMVGNYECTFCNKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQKISLN-------IHQD 404

  Fly   622 QYEADKNQPK 631
            |.||.||:.|
Worm   405 QCEAFKNRLK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	17/59 (29%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	14/67 (21%)
		C2H2 Zn finger	386..406	CDD:275368	9/48 (19%)
		zf-C2H2_8	389..465	CDD:292531	29/104 (28%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	5/26 (19%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/22 (23%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	5/20 (25%)
		zf-H2C2_2	119..143	CDD:290200	7/25 (28%)
		C2H2 Zn finger	134..154	CDD:275368	6/19 (32%)
		zf-H2C2_2	147..171	CDD:290200	9/23 (39%)
		C2H2 Zn finger	162..180	CDD:275368	5/17 (29%)
		COG5048	<187..404	CDD:227381	60/246 (24%)
		C2H2 Zn finger	191..211	CDD:275370	2/19 (11%)
		C2H2 Zn finger	218..239	CDD:275368	8/20 (40%)
		C2H2 Zn finger	248..268	CDD:275368	7/20 (35%)
		zf-H2C2_2	260..285	CDD:290200	7/25 (28%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		zf-H2C2_2	288..313	CDD:290200	7/35 (20%)
		C2H2 Zn finger	304..324	CDD:275368	7/30 (23%)
		C2H2 Zn finger	386..403	CDD:275368	5/23 (22%)
		C2H2 Zn finger	424..441	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910