DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and lin-13

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	978	Identity:	162/978 - (16%)
Similarity:	258/978 - (26%)	Gaps:	446/978 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDE--RICGRCWKIV-SDFHT 67
            ||..|..|         :.||        ...:.:||     ||..|  ..|.:|.|.. ::|..
Worm   476 SCSECNIE---------EFHS--------VVEIEEHF-----KEKHEANHTCIKCGKTFGTEFML 518

  Fly    68 LHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIE 132
            .|.    |||.              |.:|..|...::::     ...:|....||   .|.:...
Worm   519 KHH----AQSH--------------TTQTAQFANYLQMS-----ATYQPPPSSGR---LPYVGFG 557

  Fly   133 EHELDTLPRI------EILERSANTQENQDQLEGAARRLRKRL--------KAEDGSSVDKDKDE 183
                .::|.|      |:....|:..:..:.:|.....:||:|        |.|:.:..|.::.|
Worm   558 ----SSIPAIGGLTSGEVQALEASENKKSEFVEPDEYTIRKKLLRWKHAKTKKENRNITDSNEKE 618

  Fly   184 DGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDN 248
            ...|              |.:|..        :||.|..|..::..                |.:
Worm   619 FSYE--------------PGESSG--------EEDFQKSLLEQDNQ----------------SSS 645

  Fly   249 SSEDDGGSDGFDS-------------DSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAE---- 296
            ||:.|..||.|.|             |..:|..|..:.|.        ||:..|:..|..|
Worm   646 SSDSDSDSDDFTSSKQKKKRNIKIRGDLGYEHINRNKFFE--------RPESEKEARKRIEKVYK 702

  Fly   297 PKVRMSRELL---EQRKKQQEEY--------------DVIIAKFFTSVLP--------------- 329
            ..|.:|||.|   |:..:..||.              |:.::...|..||
Worm   703 KHVLLSRERLLDPEEALRILEESRMVHLNSIQSTLADDIAMSCIRTISLPASNCIDPLKDLLLVN 767

  Fly   330 -----CAICNLL----------------------------------------------------- 336
                 |..||.:
Worm   768 KIFYFCTKCNYIFSKDPVVHCLSCEVTEDDLIEVYHAASGPHAGVRCIDPECKAHLCSVISLKTH 832

  Fly   337 ---VH--------------NFTE---------MQRHH------------RLT------------- 350
               ||              ||:|         |.:|.            |.|
Worm   833 LSDVHSKQATLELVSGELDNFSENRFDRSLMLMAKHFTQLQFDERTYLARFTDIECFMPFSGLLE 897

  Fly   351 --------------HQVDPGYMMCCGRKFTQRKVLAEHVLV------------------HWNPDH 383
                          .|:.|.|.:.........:::..:.|.                  .|
Worm   898 AKDQPRPMPIRQQPQQIKPAYSLVRPDIIAPNELMRPYTLTPAIRPGQRIKPYKVPRTSRW---- 958

  Fly   384 FKCSVCEKSFQNSRHLESH-QQVHMDPAVKLTFSCDLCSKTFLSKTA------------------ 429
            :.||.|::.:::......| .:.|..|       |..|.|.|.|:..
Worm   959 YSCSWCDREYESLNQFVDHLTRFHTHP-------CPSCGKAFSSQNTRRTHVCSRLFAEIKGRGA 1016

  Fly   430 -----------------IDYHKLNKHVPKSEFKFTCSEC-------------------NKKFLTE 458
                             |..|.||:|....|:.....|.                   .:.:.:.
Worm  1017 TLCGQCPSCPEIHQVERIFVHMLNRHFSTIEYVLATGELLPPARDVGIRYNHGENGGYGRSYESL 1081

  Fly   459 RKLKNHMSSMHDPE-----------------------------STIICDKCGKQMRTKII----- 489
            |.::..:.....|:                             |..:|....|.:..:::
Worm  1082 RAIEQSVVDPRSPDYRLKQVKISALPIHGVELNRLPARDPPMGSFTVCPPKDKNIDPRLMCYMCE 1146

  Fly   490 --LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIH-VESAG--------EH---- 539
              ...:.||.|.....|| :...|..|.|.......|::|:...| |:.:|        ||
Worm  1147 LTFDSYDELTHHMDDHPE-KWANCPFCAANTPTHFDLQKHLIQEHVVQISGQACCAFCQEHHRFM 1210

  Fly   540 ------------RCHICAKVSPNARALRRHIYHNHECE-RKFKCTMCEKAFKRPQELKEHTSTHT 591
                        ||.||...|.:..|.|.||..:|... |:|:|..|.|.|....|..||.....
Worm  1211 SSHILFRCKRVSRCTICGVKSNDPLANRVHIQRSHALTLRRFQCAYCIKVFVSVGEYYEHECASG 1275

  Fly   592 GEVLYTCPNCPMTFFCSA--------NMYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKP 648
            |..:|:|...|..||.|.        :::..|.:.....|:|    |....::|..:.......|
Worm  1276 GGRVYSCTCSPNKFFNSPIEFCDHFDSVHILRNKCQLCSYDA----PSQDGMVKHRKTHMRSGCP 1336

  Fly   649 KQE 651
            |::
Worm  1337 KEQ 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	18/76 (24%)
		FYDLN_acid	<191..268	CDD:302856	16/89 (18%)
		C2H2 Zn finger	330..351	CDD:275368	12/138 (9%)
		C2H2 Zn finger	360..378	CDD:275368	1/35 (3%)
		LIM	361..>400	CDD:295319	5/56 (9%)
		C2H2 Zn finger	386..406	CDD:275368	4/20 (20%)
		zf-C2H2_8	389..465	CDD:292531	17/130 (13%)
		C2H2 Zn finger	417..438	CDD:275368	9/55 (16%)
		C2H2 Zn finger	448..465	CDD:275368	2/35 (6%)
		C2H2 Zn finger	477..498	CDD:275368	4/27 (15%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/28 (21%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368	4/20 (20%)
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100