DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and row-1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001122473.1	Gene:	row-1 / 172928	WormBaseID:	WBGene00009508	Length:	584	Species:	Caenorhabditis elegans

Alignment Length:	663	Identity:	127/663 - (19%)
Similarity:	209/663 - (31%)	Gaps:	252/663 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VALMEDD----PLTQETTSFPEIIKLATQEEEGVTEPQEL---GGRNFFYPEIKIEEHELDTLPR 141
            :.|.:||    |||...   |.::|.:|....|......:   .|:|..:.:|.|
Worm     5 ITLSDDDDDVIPLTPRP---PVVLKTSTTANHGNNSQATVHVSTGKNLNFDQIGI---------- 56

  Fly   142 IEILERSANTQENQDQLEGAARRL----RKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRP 202
                                 |||    .|...|..|:.:                |...|..||
Worm    57 ---------------------RRLSDVYNKNQPAFRGNEI----------------PTGIRNSRP 84

  Fly   203 RKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFEL 267
              |..|.|..|.|:..:||..|..: ..|....:.|
Worm    85 --SLPATAILQNPQFLVQLAAKGLK-RPFSSVHSTP----------------------------- 117

  Fly   268 DNGKQEFAVLPKRTVVR----------PKKYK-----KRTKPAEPKVRMSRELLEQRKKQQEEYD 317
                   ||:|..::.|          |..||     :.|:..||..|.||   ...||
Worm   118 -------AVVPSTSIQRTRNNQNAGNTPNIYKGHYMFEATESYEPSRRSSR---YNTKK------ 166

  Fly   318 VIIAKFFTSVLP--C-AICNLLVHNFTEMQRHHRLTH-----------QVDPGYMMCCGRKFTQR 368
             |..||..|..|  | .:|..:|.....:..|  :.|           ..|.|...|..|. :..
Worm   167 -IEGKFMCSYNPTKCYKLCGSVVEVINHIWAH--VIHDPPLPPIEKKESKDDGMFSCLLRN-SDA 227

  Fly   369 KVLAEHVLVHWNPDHFK----CSVCEKSFQNSRHLES------H-QQVHMDPAVKLTFSCDLCSK 422
            ..|||:..:     ..|    |..|...|: :.||::      | :|.|:|.      :|::|..
Worm   228 AQLAENSAL-----SLKRLQTCQFCNAVFR-TVHLKTIHVVKCHMEQDHLDT------TCNICEL 280

  Fly   423 TFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPES-TIICDKC--GKQM 484
            .|.:..|::.| :.||: ..|..:.|.:|..:.........|....|..:| |::|..|  .:.:
Worm   281 DFGNSIALNTH-MKKHI-SGEAPYNCQKCKYRTSVRAFFYQHFIEKHSNDSRTLLCPICLHHEDL 343

  Fly   485 RTKIILKKH---QELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAG-EHRCHICA 545
            |..:...||   :|.::                            ||:|   .:.| :.|||:||
Worm   344 RPNVRRSKHIFVREFVN----------------------------HMRS---HALGPQMRCHVCA 377

  Fly   546 KVSPNARALRRHIYHN----------------HECERKF-----KCTMCEKAF------KR---- 579
            ....:...|..|..::                ||.||:.     |..:.::.|      :|
Worm   378 LTFTSRLLLEAHRTNDHTMLNSLWQVIERKSVHETEREHMSKRNKIGLLQRRFFETLEGRRINDE 442

  Fly   580 -----PQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKIS 639
                 .:|.:....|.||:.|:.| .|....:.......|..:..|:..:.::.:    .|:::.
Worm   443 VACAGDKEREGFDLTTTGDTLFEC-ECGFKSWNGNRTASHYHKCRRSINDIERKR----EIVRLG 502

  Fly   640 RNASTQNKPKQEI 652
                  :.||:|:
Worm   503 ------SDPKEEL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	4/21 (19%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	9/42 (21%)
		C2H2 Zn finger	386..406	CDD:275368	7/26 (27%)
		zf-C2H2_8	389..465	CDD:292531	18/82 (22%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	2/16 (13%)
		C2H2 Zn finger	477..498	CDD:275368	6/25 (24%)
		C2H2 Zn finger	511..532	CDD:275368	3/20 (15%)
		C2H2 Zn finger	541..562	CDD:275368	6/36 (17%)
		C2H2 Zn finger	570..590	CDD:275368	3/34 (9%)
		C2H2 Zn finger	598..619	CDD:275368	3/20 (15%)
row-1	NP_001122473.1	GAT1	<15..288	CDD:227928	76/386 (20%)
		C2H2 Zn finger	244..265	CDD:275368	5/21 (24%)
		C2H2 Zn finger	275..295	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100