DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF675

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	597	Identity:	148/597 - (24%)
Similarity:	222/597 - (37%)	Gaps:	103/597 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEP--------Q 117
            |:.::..| .|:..|.|..........|.:|||             .:..|.|.||        |
Human    33 ILENYRNL-VFLGIAVSKQDLITCLEQEKEPLT-------------VKRHEMVNEPPVMCSHFAQ 83

  Fly   118 ELGGRNFFYPEIKIEE-HELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDK 181
            |      |:||..|:: .|..||.|   .|:..|   :..||:|.             .|||:.|
Human    84 E------FWPEQNIKDSFEKVTLRR---YEKCGN---DNFQLKGC-------------KSVDECK 123

  Fly   182 DEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPS 246
            ...|.........| ..:.:..:.|..|....|.....:..:|..|...|..:|....| |::..
Human   124 LHKGGYNGLNQCLP-TMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSF-CMLSH 186

  Fly   247 DNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKK 311
            ....|.:.....|....:.|....:.......||.....|.||  .:..:........|.|.:|.
Human   187 LTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYK--CQECDRTFNQFSNLTEYKKD 249

  Fly   312 QQEE--------------------YDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVD 354
            ...|                    :.:|    .|...|  |..|....:.|:.:..|.:: |..:
Human   250 YAREKPYKCEECGKAFNQSSHLTTHKII----HTGEKPYKCEECGKAFNQFSNLTTHKKI-HTGE 309

  Fly   355 PGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSC 417
            ..| :|  ||:.|||...|..|..:|.....:||..|.|:|..|..|..|:.:|..   :..:.|
Human   310 QPY-ICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTG---EQPYKC 370

  Fly   418 DLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGK 482
            :.|.|.|...:.:..|: ..|..:..:|  |.||.|.|.....|..| ..:|..|....|::|||
Human   371 EECGKAFNRSSNLTEHR-KIHTEEKPYK--CKECGKAFKHSSALTTH-KRIHTGEKPYKCEECGK 431

  Fly   483 QMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICA 545
            .......|.:|::|....||      .:|:.||......:.|.:| |.||   :||  ::|..|.
Human   432 AFNRSSKLTEHKKLHTGKKP------YKCEECGKAFIQSSKLTEH-KKIH---SGEIPYKCEECG 486

  Fly   546 KVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSAN 610
            |...::.:|..| ...|..|:.:||..|.|||.|..:|.||...||||..|.|..|...|..|||
Human   487 KAFKHSSSLTTH-KRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSAN 550

  Fly   611 MYKHRQRLHRAQ 622
            :.||: ::|..:
Human   551 LTKHK-KIHTGE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	5/19 (26%)
		FYDLN_acid	<191..268	CDD:302856	13/76 (17%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630	6/29 (21%)
		KRAB	4..43	CDD:279668	2/10 (20%)
		COG5048	169..556	CDD:227381	108/414 (26%)
		C2H2 Zn finger	174..194	CDD:275370	4/20 (20%)
		C2H2 Zn finger	202..222	CDD:275368	3/19 (16%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	258..278	CDD:275368	1/23 (4%)
		zf-H2C2_2	270..295	CDD:290200	5/28 (18%)
		C2H2 Zn finger	286..306	CDD:275368	4/20 (20%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		zf-H2C2_2	327..351	CDD:290200	8/23 (35%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	5/20 (25%)
		zf-H2C2_2	382..407	CDD:290200	8/27 (30%)
		C2H2 Zn finger	398..418	CDD:275368	7/20 (35%)
		zf-H2C2_2	410..435	CDD:290200	8/25 (32%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	6/20 (30%)
		C2H2 Zn finger	482..502	CDD:275368	5/20 (25%)
		zf-H2C2_2	494..519	CDD:290200	10/25 (40%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..558	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910