DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF679

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_699194.2	Gene:	ZNF679 / 168417	HGNCID:	28650	Length:	411	Species:	Homo sapiens

Alignment Length:	333	Identity:	85/333 - (25%)
Similarity:	131/333 - (39%)	Gaps:	48/333 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAI------------------------CN 334
            |.|..::.|.:.:..|:..:..:|.:..|...|:..|.:                        |.
Human    98 PPELGIKDSLQKVIPRRYGKSGHDNLQVKTCKSMGECEVQKGGCNEVNQCLSTTQNKIFQTHKCV 162

  Fly   335 LLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSR 397
            .:...|:...||.  |......:..|  .|:.|.....|.:|.::|...:.::|..|.|.|..|.
Human   163 KVFGKFSNSNRHK--TRHTGKKHFKCKKYGKSFCMVSQLHQHQIIHTRENSYQCEECGKPFNCSS 225

  Fly   398 HLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLK 462
            .|..|:::|..   :..:.|:.|.|.|...:.:..|   :.:...|..:||.||.:.|.....|.
Human   226 TLSKHKRIHTG---EKPYRCEECGKAFTWSSTLTKH---RRIHTGEKPYTCEECGQAFSRSSTLA 284

  Fly   463 NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            || ..:|..|....|::|||.......|..|:.:...:||      ..|:.||......:.||:|
Human   285 NH-KRIHTGEKPYTCEECGKAFSLSSSLTYHKRIHTGEKP------YTCEECGKAFNCSSTLKKH 342

  Fly   528 MKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTH 590
             |.||   .||  ::|..|.|....:..|..| ...|..|..:||..|:||||....|..|.|.|
Human   343 -KIIH---TGEKPYKCKECGKAFAFSSTLNTH-KRIHTGEEPYKCEECDKAFKWSSSLANHKSMH 402

  Fly   591 TGEVLYTC 598
            |||..|.|
Human   403 TGEKPYKC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/44 (11%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	1/1 (100%)
ZNF679	NP_699194.2	KRAB	16..76	CDD:214630
		KRAB	16..55	CDD:279668
		C2H2 Zn finger	159..178	CDD:275368	5/20 (25%)
		C2H2 Zn finger	186..206	CDD:275368	5/19 (26%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		zf-H2C2_2	227..250	CDD:290200	6/25 (24%)
		COG5048	<238..401	CDD:227381	51/177 (29%)
		C2H2 Zn finger	242..262	CDD:275368	5/22 (23%)
		zf-H2C2_2	255..279	CDD:290200	7/26 (27%)
		C2H2 Zn finger	270..290	CDD:275368	7/20 (35%)
		zf-H2C2_2	283..306	CDD:290200	9/23 (39%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		zf-H2C2_2	310..335	CDD:290200	7/30 (23%)
		C2H2 Zn finger	326..346	CDD:275368	7/20 (35%)
		zf-H2C2_2	339..362	CDD:290200	11/26 (42%)
		C2H2 Zn finger	354..374	CDD:275368	5/20 (25%)
		zf-H2C2_2	367..390	CDD:290200	9/23 (39%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910