DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF540

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001165696.1	Gene:	ZNF540 / 163255	HGNCID:	25331	Length:	660	Species:	Homo sapiens

Alignment Length:	334	Identity:	99/334 - (29%)
Similarity:	136/334 - (40%)	Gaps:	44/334 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 KFFTSVLP--CAICN---LLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHW 379
            |..|.|.|  |..|.   .|....||    ||.||.....| .|  ||:.|..|..|..|..:|.
Human   347 KIHTGVKPYECKECGKTFRLSFYLTE----HRRTHAGKKPY-ECKECGKSFNVRGQLNRHKTIHT 406

  Fly   380 NPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYH-KLNKHVPKSE 443
            ....|.|.||||:|..|..|..|.::|..   :..:.|..|.|.|:.::.:..| :|:..|...|
Human   407 GIKPFACKVCEKAFSYSGDLRVHSRIHTG---EKPYECKECGKAFMLRSVLTEHQRLHTGVKPYE 468

  Fly   444 FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPEL 508
                |.||.|.|....::..| ..:|.......|.:|||..|....|.:||.:...:||
Human   469 ----CKECGKTFRVRSQISLH-KKIHTDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKP------ 522

  Fly   509 QQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMC 573
            .:|:.||........||:|:| || .....:.|..|.|..........| ...|...:.:||..|
Human   523 YKCKECGKAFIRRGNLKEHLK-IH-SGLKPYDCKECGKSFSRRGQFTEH-QKIHTGVKPYKCKEC 584

  Fly   574 EKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YEADKNQPKPPNIL 636
            .|||.|..:|:.|...||||..|.|..|...|..::::.:| ||:|..:  ||.
Human   585 GKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNSHLTEH-QRIHTGEKPYEC----------- 637

  Fly   637 KISRNASTQ 645
            |:.|.|..|
Human   638 KVCRKAFRQ 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	7/23 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	21/76 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/21 (29%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF540	NP_001165696.1	KRAB	6..66	CDD:214630
		C2H2 Zn finger	189..209	CDD:275368
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	241..620	CDD:227381	89/294 (30%)
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368	1/1 (100%)
		C2H2 Zn finger	357..377	CDD:275368	7/23 (30%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	6/20 (30%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		C2H2 Zn finger	553..573	CDD:275368	4/20 (20%)
		C2H2 Zn finger	581..601	CDD:275368	8/19 (42%)
		C2H2 Zn finger	609..629	CDD:275368	6/20 (30%)
		zf-H2C2_2	621..646	CDD:316026	9/36 (25%)
		C2H2 Zn finger	637..657	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910