DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF100

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_775802.2	Gene:	ZNF100 / 163227	HGNCID:	12880	Length:	542	Species:	Homo sapiens

Alignment Length:	412	Identity:	106/412 - (25%)
Similarity:	166/412 - (40%)	Gaps:	61/412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EDIQLDLKAEELDEF-VDEETDPDFS-CLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLP- 278
            :::||....:.:||. |.:|.|...: ||:.:.::.              |:.|...:.|....
Human   141 DNLQLQKGCKSVDECKVHKEHDNKLNQCLITTQSNI--------------FQCDPSAKVFHTFSN 191

  Fly   279 ------KRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLV 337
                  :.|..:|.|.||    .|....|...|.:.::....|          :...|..|....
Human   192 SNRHKIRHTRKKPFKCKK----CEKSFCMLLHLTQHKRFHITE----------NSYQCKDCGKAF 242

  Fly   338 HNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLE 400
            :.|:.:..|.|: |..:..| .|  ||:.|.:...|..|.::|.....::|..|.|:|..|.||.
Human   243 NWFSTLTTHRRI-HTGEKPY-KCEECGKAFNRSSHLTTHKIIHTGEKPYRCEECGKAFNRSSHLT 305

  Fly   401 SHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHM 465
            :|:::|  ..|| .:.|..|.|.|...:.:..|::   :...|..:.|.||.|.|.....|..|.
Human   306 THKRIH--TGVK-PYKCTECGKAFNRSSHLTTHRI---IHTGEKPYKCEECGKAFNQSSTLTTHK 364

  Fly   466 SSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKS 530
            .: |..|....|::|||.......|.||:.....:|      ..:|:.||......:.|.:| |.
Human   365 IT-HAGEKPYKCEECGKAFYRFSYLTKHKTSHTGEK------FYKCEECGKGFNWSSALTKH-KR 421

  Fly   531 IHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGE 593
            ||   .||  ::|..|.|....:..|..| ...|..|:.:||..|.|||.|..:|..|...||||
Human   422 IH---TGEKPYKCEECGKAFNESSNLTTH-KMIHTGEKPYKCDECGKAFNRSSQLTAHKMIHTGE 482

  Fly   594 VLYTCPNCPMTFFCSANMYKHR 615
            ..|.|..|...|..|:.:.||:
Human   483 KPYKCEECGKAFNRSSTLTKHK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	10/52 (19%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/18 (33%)
ZNF100	NP_775802.2	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	150..534	CDD:227381	104/403 (26%)
		C2H2 Zn finger	207..227	CDD:275368	5/23 (22%)
		C2H2 Zn finger	235..255	CDD:275368	5/20 (25%)
		zf-H2C2_2	248..272	CDD:290200	8/25 (32%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:290200	7/24 (29%)
		C2H2 Zn finger	291..311	CDD:275368	8/19 (42%)
		zf-H2C2_2	303..328	CDD:290200	10/27 (37%)
		C2H2 Zn finger	319..339	CDD:275368	5/22 (23%)
		zf-H2C2_2	331..356	CDD:290200	7/27 (26%)
		C2H2 Zn finger	347..367	CDD:275368	7/20 (35%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	6/20 (30%)
		zf-H2C2_2	415..439	CDD:290200	10/27 (37%)
		C2H2 Zn finger	431..451	CDD:275368	5/20 (25%)
		zf-H2C2_2	443..468	CDD:290200	10/25 (40%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..496	CDD:290200	10/23 (43%)
		C2H2 Zn finger	487..507	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910