DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZFP1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_016878472.1	Gene:	ZFP1 / 162239	HGNCID:	23328	Length:	455	Species:	Homo sapiens

Alignment Length:	441	Identity:	97/441 - (21%)
Similarity:	165/441 - (37%)	Gaps:	127/441 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 FSCL---VPSDNSSEDDGGSDGFDSDSDFELDNGK-----QEFAVLPKRTVVR------------ 284
            :.||   :|...::|::...:.:.:|...|.|:..     ::|.:|..:|.:.
Human    76 YFCLHSSLPLPKTAENEQIPEVWKADDQMERDHRNPDEQARQFLILKNQTPIEERGDLFGKALNL 140

  Fly   285 ----------PKKYKKRTKPAEPKVRMSRELLEQRK----KQQEEYDVIIAKFFTSVLPCAICN- 334
                      |.||..    .|..::.:.:||...:    ||.:|                 ||
Human   141 NTDFVSLRQVPYKYDL----YEKTLKYNSDLLNSNRSYAGKQTDE-----------------CNE 184

  Fly   335 ----LL------VHNFTEMQ----------------RHHRLTHQVDPGYMMCCGRKFTQRKVLAE 373
                ||      .|:..|..                :|.::.:.|.|.....|.:.|:.:.:|..
Human   185 FGKALLYLKQEKTHSGVEYSEYNKSGKALSHKAAIFKHQKIKNLVQPFICTYCDKAFSFKSLLIS 249

  Fly   374 HVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH 438
            |..:|.....::|:||:|:|.:..:|..||::|..   :..|.|..|.|.|..::.:..|: ..|
Human   250 HKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTG---EKPFECPECGKAFTHQSNLIVHQ-RAH 310

  Fly   439 VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPR 503
            :.|..::  ||||.|.|..:.:|..| ..:|..|....|::|.|....|..|..||:: |:.:.|
Human   311 MEKKPYE--CSECGKTFAQKFELTTH-QRIHTGERPYECNECAKTFFKKSNLIIHQKI-HTGEKR 371

  Fly   504 PEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKF 568
            .|     |..||......:.|..||::                               |..|:.:
Human   372 YE-----CSECGKSFIQNSQLIIHMRT-------------------------------HTGEKPY 400

  Fly   569 KCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            :||.|.|.|.:...|:.|...||||..|.|..|...|...:.:..| ||:|
Human   401 ECTECGKTFSQRSTLRLHLRIHTGEKPYECSECGKAFSRKSRLSVH-QRVH 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	6/30 (20%)
		C2H2 Zn finger	330..351	CDD:275368	7/47 (15%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	0/20 (0%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZFP1	XP_016878472.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910