DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF782

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	666	Identity:	143/666 - (21%)
Similarity:	244/666 - (36%)	Gaps:	157/666 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LQETKVALMEDDPLTQETTSFPEIIKLATQEEEG------------VTEPQELGGR------NFF 125
            |::.|..|..:.|    ..|.|:.|...:.|.:|            :|..||:.|:      |.|
Human    69 LEKEKGFLSRNSP----EDSQPDEISEKSPENQGKHLLQVLFTNKLLTTEQEISGKPHNRDINIF 129

  Fly   126 YPEI-------------------------KIEEHELDTLPR--IEILERSANTQENQDQLEGAAR 163
            ...:                         |.:.||.:...:  |.|.:...||||.........:
Human   130 RARMMPCKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGRTNTQEKSFAYSKIVK 194

  Fly   164 RLRKR---LKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKA 225
            .|..:   ::.:...::.:|.:.:           :.|:....|:....:....||.      |:
Human   195 TLHHKEEVIQHQTIQTLGQDFEYN-----------ESRKAFLEKAALVTSNSTHPKG------KS 242

  Fly   226 EELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKK 290
            ...::|.:.:.|.. :.::|.:.:.|          .|.:|.::....|..:..:|:...|.:.:
Human   243 YNFNKFGENKYDKS-TFIIPQNMNPE----------KSHYEFNDTGNCFCRITHKTLTGGKSFSQ 296

  Fly   291 RT------------KPAEPKVRMSREL---LEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNF 340
            ::            ||.|.....:|..   :.||....::|        :...||.........|
Human   297 KSHIREHHRVHIGVKPFEYGKSFNRNSTLPVHQRTHATDKY--------SDYHPCTETFSYQSTF 353

  Fly   341 TEMQRHH------------------------RLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHW 379
            :..|:.|                        :.:|..:..| .|  ||:.|:::..|.:|...|.
Human   354 SVHQKVHIRAKPYEYNECGKSCSMNSHLIWPQKSHTGEKPY-ECPECGKAFSEKSRLRKHQRTHT 417

  Fly   380 NPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEF 444
            ....:||..|:|:|.....|..||:.|..   :..|.|..|.|:|..|:.:..|: ..|.  .|.
Human   418 GEKPYKCDGCDKAFSAKSGLRIHQRTHTG---EKPFECHECGKSFNYKSILIVHQ-RTHT--GEK 476

  Fly   445 KFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQ 509
            .|.|:||.|.|.....|:||..: |..|....||:|||..:.|..|:||......:||      .
Human   477 PFECNECGKSFSHMSGLRNHRRT-HTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKP------Y 534

  Fly   510 QCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTM 572
            :|..||.    ..|.|..::..|....||  ::|:.|.:.......||.| :..|..|:.::|..
Human   535 KCNQCGK----AFGQKSQLRGHHRIHTGEKPYKCNHCGEAFSQKSNLRVH-HRTHTGEKPYQCEE 594

  Fly   573 CEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQ-----PKP 632
            |.|.|::...|:.|..|||||..|.|..|...|...:.:.|| ||.|..:...:.||     .:.
Human   595 CGKTFRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKH-QRTHTGEKPYNCNQCGEAFSQK 658

  Fly   633 PNILKISRNASTQNKP 648
            .| |::.:...|..||
Human   659 SN-LRVHQRTHTGEKP 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	1/1 (100%)
		FYDLN_acid	<191..268	CDD:302856	11/76 (14%)
		C2H2 Zn finger	330..351	CDD:275368	4/44 (9%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95		5/23 (22%)
		C2H2 Zn finger	291..307	CDD:275368	1/15 (7%)
		C2H2 Zn finger	314..332	CDD:275368	4/17 (24%)
		C2H2 Zn finger	343..360	CDD:275368	3/16 (19%)
		C2H2 Zn finger	369..388	CDD:275368	0/18 (0%)
		COG5048	392..697	CDD:227381	90/303 (30%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..432	CDD:290200	7/22 (32%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:290200	9/26 (35%)
		C2H2 Zn finger	452..472	CDD:275368	6/20 (30%)
		zf-H2C2_2	465..489	CDD:290200	9/26 (35%)
		C2H2 Zn finger	480..500	CDD:275368	8/20 (40%)
		zf-H2C2_2	493..516	CDD:290200	10/23 (43%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		zf-H2C2_2	521..543	CDD:290200	8/31 (26%)
		C2H2 Zn finger	536..556	CDD:275368	6/23 (26%)
		zf-H2C2_2	549..573	CDD:290200	5/23 (22%)
		C2H2 Zn finger	564..584	CDD:275368	5/20 (25%)
		zf-H2C2_2	576..601	CDD:290200	9/25 (36%)
		C2H2 Zn finger	592..612	CDD:275368	6/19 (32%)
		zf-H2C2_2	604..628	CDD:290200	10/23 (43%)
		C2H2 Zn finger	620..640	CDD:275368	7/20 (35%)
		zf-H2C2_2	633..657	CDD:290200	7/24 (29%)
		C2H2 Zn finger	648..668	CDD:275368	4/20 (20%)
		zf-H2C2_2	660..685	CDD:290200	5/15 (33%)
		C2H2 Zn finger	676..696	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910