DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF425

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001001661.1	Gene:	ZNF425 / 155054	HGNCID:	20690	Length:	752	Species:	Homo sapiens

Alignment Length:	637	Identity:	150/637 - (23%)
Similarity:	231/637 - (36%)	Gaps:	159/637 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLP 140
            |..|.:|:   ....|.|.|..:.....||...::||.             |..|.|:..|
Human    72 QGCLDKTR---RTTSPPTDEQLNMKNTGKLLCFDDEGT-------------PRTKEEDCRL---- 116

  Fly   141 RIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDE-----DGVEETAEPAPPKKRRG 200
                     |..:.||.......:.||.|.|:..:.......|     ..|..||.....|..|.
Human   117 ---------NGPQKQDLCAALRGKERKILLAQTATFQSPSLRETEILNKKVSITAYDPDKKDLRH 172

  Fly   201 RPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDF 265
            :||::...:..|..|:                      .:||.|
Human   173 KPRETPGRLEIPTGPR----------------------CYSCYV--------------------- 194

  Fly   266 ELDNGKQEFAVLPKRTVVRPK------------KYKKRTKPAEPKVRMSRELLEQRKKQQ----E 314
                .::.|.|  :|.:::.|            |||..:: .:.::|.::.||.|:|:.|    |
Human   195 ----CRKVFQV--RRDLLKHKRSHSKSQLCRYPKYKNSSR-GKSELRRTQRLLCQKKRFQCSECE 252

  Fly   315 EYDVIIAKFFTSVL--------PCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVL 371
            :...:.....|..:        ||..|:........:::|..|.....|.....|||.|.|:..|
Human   253 KSYFLKGSLVTHQVVHTGQRPYPCPECDKTFRYRANLKKHLCLHRGERPFCCGECGRAFVQQCEL 317

  Fly   372 AEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLN 436
            .||:.:|.....|:|..|::.|:..|.::.|...|   :.|..|.|..|.::|..|.|:   |.:
Human   318 TEHLRLHSGEKPFQCPQCDRCFRLKRGMKVHLTQH---SGKRPFHCPECGRSFSRKAAL---KTH 376

  Fly   437 KHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH-------- 493
            :.....|..|:|.||.:||:.:.||..|: .:|..|....|.:|.|..|.|..||.|
Human   377 QRTHSEEKPFSCGECGRKFIYKIKLDEHI-RVHTGEKPFSCPECNKSFRLKRSLKAHGLQHIGKR 440

  Fly   494 -------------------QELMHSD-KPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE 538
                               .:.:||: ||.|      |..||......:.|..|.: :| :...|
Human   441 PFQCPECSRGFFWRNAMRAHQRLHSEQKPFP------CAECGKRFTRPSKLACHTR-VH-DRQKE 497

  Fly   539 HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPM 603
            ..|..|.|.......|.:|: ..|..|:.|.|..|.::|:|...|.|||..|:||..:.||.|..
Human   498 FPCGECKKTFSQQSRLTQHL-KVHTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDK 561

  Fly   604 TFFCSANMYKHRQRLHR-----AQYEADKNQPKPPNILKISRNASTQNKPKQ 650
            :|...|:| |..||:||     |..|.||.......:.:..|..|.: ||.|
Human   562 SFSWKASM-KFHQRMHRDEKPFACGECDKTYTHQSQLTEHLRLHSGE-KPYQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	2/4 (50%)
		FYDLN_acid	<191..268	CDD:302856	9/76 (12%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	8/17 (47%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	8/47 (17%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
ZNF425	NP_001001661.1	KRAB	9..64	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	192..212	CDD:275368	6/46 (13%)
		C2H2 Zn finger	248..268	CDD:275368	2/19 (11%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		COG5048	355..731	CDD:227381	79/272 (29%)
		zf-C2H2	358..380	CDD:278523	7/24 (29%)
		C2H2 Zn finger	360..380	CDD:275368	6/22 (27%)
		C2H2 Zn finger	388..408	CDD:275368	8/20 (40%)
		zf-H2C2_2	401..423	CDD:290200	7/22 (32%)
		C2H2 Zn finger	416..432	CDD:275368	7/15 (47%)
		C2H2 Zn finger	444..464	CDD:275368	0/19 (0%)
		C2H2 Zn finger	472..492	CDD:275368	5/20 (25%)
		C2H2 Zn finger	500..520	CDD:275368	5/20 (25%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		zf-H2C2_2	540..564	CDD:290200	10/23 (43%)
		C2H2 Zn finger	556..576	CDD:275368	9/20 (45%)
		C2H2 Zn finger	584..604	CDD:275368	4/19 (21%)
		zf-H2C2_2	597..619	CDD:290200	5/16 (31%)
		C2H2 Zn finger	612..632	CDD:275368	150/637 (24%)
		C2H2 Zn finger	640..660	CDD:275368
		zf-H2C2_2	653..675	CDD:290200
		C2H2 Zn finger	668..688	CDD:275368
		zf-H2C2_2	680..705	CDD:290200
		C2H2 Zn finger	696..716	CDD:275368
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910