DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF595

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_872330.1	Gene:	ZNF595 / 152687	HGNCID:	27196	Length:	648	Species:	Homo sapiens

Alignment Length:	324	Identity:	96/324 - (29%)
Similarity:	138/324 - (42%)	Gaps:	51/324 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKS 392
            |..|....:..|.:.:|.|: |..:..| .|  ||:.|.:..||.||..:|.....:||..|.|:
Human   202 CEKCGKAFNRSTSLSKHKRI-HTGEKPY-TCEECGKAFRRSTVLNEHKKIHTGEKPYKCEECGKA 264

  Fly   393 FQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLT 457
            |..|..|..|:::|..   :..:.|..|.|.|...|:::.|| |.|..:..:|  |.||.|.|..
Human   265 FTRSTTLNEHKKIHTG---EKPYKCKECGKAFRWSTSLNEHK-NIHTGEKPYK--CKECGKAFRQ 323

  Fly   458 ERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMT 522
            .|.|..| .::|..|....|:||||.......|..|:.: ||     |.:|.:|:.||......:
Human   324 SRSLNEH-KNIHTGEKPYTCEKCGKAFNQSSSLIIHRSI-HS-----EQKLYKCEECGKAFTWSS 381

  Fly   523 GLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH-------------------------IYH 560
            .|.:| |.||   .||  :.|..|.|....:..|.:|                         |.|
Human   382 SLNKH-KRIH---TGEKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGKAFNQSSTLILH 442

  Fly   561 N--HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            .  |..::.:||..|.|||.|...|.||...||||..|.|..|...|..||::.:|: .:|..:
Human   443 KRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGKAFIWSASLNEHK-NIHTGE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/47 (15%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..194	CDD:275368
		COG5048	198..599	CDD:227381	96/324 (30%)
		C2H2 Zn finger	202..222	CDD:275368	5/20 (25%)
		C2H2 Zn finger	230..250	CDD:275368	8/19 (42%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	286..306	CDD:275368	8/20 (40%)
		C2H2 Zn finger	314..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	342..362	CDD:275368	7/20 (35%)
		C2H2 Zn finger	370..390	CDD:275368	6/20 (30%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	426..446	CDD:275368	2/19 (11%)
		C2H2 Zn finger	454..474	CDD:275368	9/19 (47%)
		C2H2 Zn finger	482..502	CDD:275368	6/20 (30%)
		C2H2 Zn finger	510..530	CDD:275368
		C2H2 Zn finger	538..558	CDD:275368
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910