DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF714

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_872321.2	Gene:	ZNF714 / 148206	HGNCID:	27124	Length:	555	Species:	Homo sapiens

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	171/408 - (41%)	Gaps:	74/408 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 NGKQEFAVLPKR----TVVRPKKYKK--------------RTKPAEPKVRMSRELLEQR------ 309
            :||.|...|..|    .||..|.|||              :..|.:..:::..::....
Human    75 HGKCEHENLQLRKGSANVVECKVYKKGYNELNQCLTTTQSKIFPCDKYIKVFHKIFNSNRHKTRH 139

  Fly   310 --------KKQQEEYDVII-------AKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMM 359
                    ||..|.:.:::       .....:...|..|:.:...|:.:.||.|:.....|....
Human   140 TGEKPFKCKKCDESFCMLLHLHQHKRIHIRENSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKCE 204

  Fly   360 CCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTF 424
            .||:.|.....|..|.::|.....::|..|.|:|.:|.||.:|:.:|..   :..|.|:.|.|.|
Human   205 ECGKAFKHSSTLTTHKMIHTGEKPYRCEECGKAFYHSSHLTTHKVIHTG---EKPFKCEECGKAF 266

  Fly   425 LSKTAIDYHKLNKHVPKSEFKFTCSECNKKF-----LTERKLKNHMSSMHDPESTIICDKCGKQM 484
            ...:|:..||. .||.:..:|  |.||:|.|     ||:.|:      :|..|.:..|::|||..
Human   267 NHPSALTTHKF-IHVKEKPYK--CEECDKAFNRFSYLTKHKI------IHSGEKSYKCEQCGKGF 322

  Fly   485 RTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKV 547
            .....|.||:.:...:||      .:|:.||......:.|..| |.||   .||  ::|..|.|.
Human   323 NWSSTLTKHKRIHTGEKP------YKCEECGKAFNVSSHLTTH-KMIH---TGEKPYKCEECGKA 377

  Fly   548 SPNARALRRH-IYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANM 611
            ..::..|..| |.|..  |:.:||..|.|||.:...|.:|...||||.||.|..|...|..|:|:
Human   378 FNHSSKLTIHKIIHTG--EKPYKCEECGKAFNQSSNLTKHKIIHTGEKLYKCEECGKAFNRSSNL 440

  Fly   612 YKHRQRLHRAQ--YEADK 627
            ..|: |:|..:  |:.::
Human   441 TTHK-RIHTGEKPYKCEE 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	27/80 (34%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	8/21 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/21 (33%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF714	NP_872321.2	KRAB	<2..36	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	3/19 (16%)
		COG5048	171..504	CDD:227381	93/312 (30%)
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		zf-H2C2_2	188..212	CDD:290200	7/23 (30%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	8/19 (42%)
		zf-H2C2_2	243..268	CDD:290200	9/27 (33%)
		C2H2 Zn finger	259..279	CDD:275368	7/20 (35%)
		C2H2 Zn finger	287..307	CDD:275368	8/25 (32%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..351	CDD:290200	8/28 (29%)
		C2H2 Zn finger	343..363	CDD:275368	6/20 (30%)
		zf-H2C2_2	355..380	CDD:290200	10/28 (36%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..408	CDD:290200	11/25 (44%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	411..436	CDD:290200	11/24 (46%)
		C2H2 Zn finger	427..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	5/20 (25%)
		C2H2 Zn finger	455..475	CDD:275368	0/3 (0%)
		zf-H2C2_2	467..492	CDD:290200
		C2H2 Zn finger	483..502	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910