DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF560

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	642	Identity:	133/642 - (20%)
Similarity:	224/642 - (34%)	Gaps:	160/642 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELG----- 120
            ::.|:...|:   .:.|:||:....:...:.:..:..:|..:....||||..:.:|.:..
Human    77 VLQDWAIKHQ---TSVSALQQEFWKIQTSNGIQMDLVTFDSVAVEFTQEEWTLLDPAQRNLYSDV 138

  Fly   121 -----------GRNFFYPEI---KIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKA 171
                       |...|.|.:   ..||.||.||||:                   .:..:..||.
Human   139 MLENYKNLSSVGYQLFKPSLISWLEEEEELSTLPRV-------------------LQEWKMCLKT 184

  Fly   172 EDGSSVDKD----KDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFV 232
            : |.::.:|    |..:|::..      :.:.|                            :|..
Human   185 K-GPALWQDNFCLKTLNGIQLA------RNQNG----------------------------EELY 214

  Fly   233 DEETDPDFSCLVP---SDNSSEDDGGSD-----GFDSDSDFELDNGKQEFAVLPK-----RTVVR 284
            |.:...|..|..|   ::.|:::.|.:.     ..|..|.:...:..::.:|..|     |.::.
Human   215 DCKQCEDVFCKHPCLKTNMSTQNRGNTSECIQYAKDLLSLYNKTSTIRKVSVFSKHGKSFRLILN 279

  Fly   285 PKKYKKRTKPAE------PKVRMSRELLEQRKKQQ-----EEYDVIIAKFFTSV----------- 327
            .:..:|.|:...      .|..:.:..||..:|.|     .|:......|..|.
Human   280 VQVQRKCTQDKSFEGTDYGKAFIYQSYLEAHRKTQSGEKLNEWKQCGEAFTHSTSHAVNVETHII 344

  Fly   328 ---LPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
               ..|..|.......|.:..|.:....:.|.....||:.||......|||..|.....:.|..|
Human   345 KNPYECKECGKDFRYPTHLNNHMQTHIGIKPYKCKHCGKTFTVPSGFLEHVRTHTGEKPYGCKEC 409

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTA----IDYHKLNKHVPKSEF------ 444
            .|:|..|..|..|.:.|   |.:.||.||.|.|.|:|..:    :..|...|.....|:
Human   410 GKAFGTSAGLIEHIRCH---AREKTFKCDHCGKAFISYPSLFGHLRVHNGEKPYEHKEYGKAFGT 471

  Fly   445 ---------------KFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQ 494
                           :|.|.:|.|.|::...|..|:.: |..|....|.||||...:...|:.|.
Human   472 SSGVIEDRRSNTGQKRFDCDQCGKVFVSFSSLFAHLRT-HTGEKPFKCYKCGKPFTSSACLRIHM 535

  Fly   495 ELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH 557
                  :...|..|.||:.||......:.|.:|:::    .|||  :.|..|.|.......|.:|
Human   536 ------RTHTEERLYQCKKCGKAFTKCSYLTKHLRT----HAGEKPYECMKCGKAFTERSYLTKH 590

  Fly   558 IYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKH 614
            : ..|..|:.::|..|.|||....:|.:|...|||:..|...:|...|..|:::..|
Human   591 L-RRHSGEKPYECKKCGKAFTERSDLTKHLRRHTGDKPYEYKDCGKAFVVSSSLVDH 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	4/19 (21%)
		FYDLN_acid	<191..268	CDD:302856	10/84 (12%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	25/100 (25%)
		C2H2 Zn finger	417..438	CDD:275368	7/24 (29%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	4/17 (24%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630	9/50 (18%)
		KRAB	110..149	CDD:279668	6/38 (16%)
		C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		C2H2 Zn finger	323..342	CDD:275368	2/18 (11%)
		COG5048	344..754	CDD:227381	82/318 (26%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		zf-H2C2_2	362..386	CDD:290200	4/23 (17%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..510	CDD:275368	6/20 (30%)
		zf-H2C2_2	502..527	CDD:290200	9/25 (36%)
		C2H2 Zn finger	518..538	CDD:275368	7/25 (28%)
		zf-H2C2_2	531..554	CDD:290200	8/28 (29%)
		C2H2 Zn finger	546..566	CDD:275368	5/23 (22%)
		zf-H2C2_2	558..582	CDD:290200	8/27 (30%)
		C2H2 Zn finger	574..594	CDD:275368	5/20 (25%)
		zf-H2C2_2	586..610	CDD:290200	8/24 (33%)
		zf-C2H2	600..622	CDD:278523	7/21 (33%)
		C2H2 Zn finger	602..622	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	4/17 (24%)
		C2H2 Zn finger	658..678	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	726..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910