DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF513

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_653232.3	Gene:	ZNF513 / 130557	HGNCID:	26498	Length:	541	Species:	Homo sapiens

Alignment Length:	545	Identity:	111/545 - (20%)
Similarity:	183/545 - (33%)	Gaps:	172/545 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PKKRRGRPR-------KSDAAVAPPQKP-----KEDIQL--DLKAEELDEFVDEETDPDFSCLVP 245
            |::::..|:       |.|...:..:.|     :.|:.|  ||:.||.:|  :||.|.:...|:.
Human     2 PRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEE--EEEGDGNSDQLMG 64

  Fly   246 SDNSSEDD--GGSDGFDSD-SDFELDNGKQEFAVLPKRTVVRPKK--YKKRTKPAEPKVRM---- 301
            .:..||.|  |...|.... ||.|...|:   |:..:..|..|.:  .:.|.:...|..::
Human    65 FERDSEGDSLGARPGLPYGLSDDESGGGR---ALSAESEVEEPARGPGEARGERPGPACQLCGGP 126

  Fly   302 -------------SRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQV 353
                         ...||..|                .:..|.:|..:.|..:.::||.: ||..
Human   127 TGEGPCCGAGGPGGGPLLPPR----------------LLYSCRLCTFVSHYSSHLKRHMQ-THSG 174

  Fly   354 DPGYMMCCGR---KFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTF 415
            :..:.  |||   ...|...|..|...|.....::|..|..:..:..:|..||:.|..|.   |.
Human   175 EKPFR--CGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPP---TP 234

  Fly   416 SCDLCSKTFLS--------------------KTAIDYHKLNKHVPK------------------- 441
            .|..|.....:                    :.|:....|:.|||.
Human   235 PCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGL 299

  Fly   442 ----SE------FKFTCSECNKKFLTERKLKNHMSSMHDPE-STIICDKCGKQMRTKI------- 488
                ||      |.:||..|.::             :.:.| |.:....||:.||.:.
Human   300 CGTGSEPLPELLFPWTCRGCGQE-------------LEEGEGSRLGAAMCGRCMRGEAGGGASGG 351

  Fly   489 ----------------------ILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSI 531
                                  .|.:|.:....:||      .:|..|......:..||:|.: :
Human   352 PQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKP------FRCARCPYASAHLDNLKRHQR-V 409

  Fly   532 HVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEV 594
            |   .||  ::|.:|.....|...|:|| ...|..::.|:|::|..:..:...||.|...||||.
Human   410 H---TGEKPYKCPLCPYACGNLANLKRH-GRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEK 470

  Fly   595 LYTCPNCPMTFFCSANMYKHRQRLH 619
            .:.|..|..|.....| ||..|::|
Human   471 PFRCATCAYTTGHWDN-YKRHQKVH 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	24/89 (27%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/20 (30%)
		LIM	361..>400	CDD:295319	9/41 (22%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	20/124 (16%)
		C2H2 Zn finger	417..438	CDD:275368	4/40 (10%)
		C2H2 Zn finger	448..465	CDD:275368	2/16 (13%)
		C2H2 Zn finger	477..498	CDD:275368	6/49 (12%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF513	NP_653232.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		29/120 (24%)
		C2H2 Zn finger	152..172	CDD:275368	5/20 (25%)
		COG5048	176..>228	CDD:227381	12/53 (23%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		zf-H2C2_2	192..217	CDD:316026	5/24 (21%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		COG5048	<372..>450	CDD:227381	21/88 (24%)
		C2H2 Zn finger	390..410	CDD:275368	5/20 (25%)
		COG5048	414..>487	CDD:227381	21/74 (28%)
		C2H2 Zn finger	418..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..493	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..541		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100