DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP011759

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_320751.4	Gene:	AgaP_AGAP011759 / 1280881	VectorBaseID:	AGAP011759	Length:	830	Species:	Anopheles gambiae

Alignment Length:	828	Identity:	167/828 - (20%)
Similarity:	243/828 - (29%)	Gaps:	350/828 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 FPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAAR 163
            ||.|  |.|::....|..|.:..||......|:..::||...|.            :|:......
Mosquito    44 FPNI--LLTKKIYDCTSIQIIYERNLPMFVCKLCANKLDEYVRF------------RDRCIANDE 94

  Fly   164 RLRKRLKAED----GSSVDKDKDEDGVEETAEPAPPKKRRGRPR-----------------KSDA 207
            .||..|.|.|    ||.....|.|.  ::||.||.|.:.....:                 ::.|
Mosquito    95 FLRNALAAFDANGGGSCPGAIKMEP--DDTAHPAVPPQPPASAKFAQCLAVTPLELNCALVEAAA 157

  Fly   208 AVAPPQKPKEDIQLDLKAEELDE-------------------FVDEET-------DPDFSCLVPS 246
            |.|..::|.:       .||.||                   .|||.|       :|.:
Mosquito   158 AAAGKREPPD-------IEEEDEERGYGHGSGAPSPDRSACGRVDELTVKRPHSDEPHY------ 209

  Fly   247 DNSSEDDG--GSDGFDSD-SDFELDNGKQEFAVLPKRTVVRPKKYKKR----------------- 291
            .:..|||.  ..||:|.: :....::..|:..|..    |..|.:|.|
Mosquito   210 HSGDEDDELLADDGYDGEPNQTPAEHADQQQYVCE----VCSKSFKIRHHLLVHRHTHVDSHAPT 270

  Fly   292 --------------------------TKPAEPKVRMSR-ELLEQRKKQQEE-------------Y 316
                                      :.|..||..::: .||...:....|             |
Mosquito   271 ADMLHERADFNGATPGAGGAGGKPSYSCPKCPKAFVNKGNLLNHLETHTHEKSYACDICTKTFKY 335

  Fly   317 DV---IIAKFFTSVLP--CAICNLLVHNFTEMQ--RHHRLTH-QVDPGYMMCCGRKFTQRKVLAE 373
            :|   :..:..|...|  |.|||   ..|:::.  |.||.|| :|.|.....|.:.||....|..
Mosquito   336 NVQLRLHMRIHTGERPHKCEICN---RGFSQLSNLRSHRKTHSKVKPYKCHLCLKSFTMLDNLTA 397

  Fly   374 HVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH 438
            | ......|.|:|::|.|||....:|.||.|.|.|..|:..|.|::|.|:|.:|.  |: |.:..
Mosquito   398 H-SAKCLKDKFRCTLCSKSFAKEGNLLSHLQSHSDGIVEKMFKCEMCPKSFKNKE--DW-KRHVR 458

  Fly   439 VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH---------- 493
            |...|..:||..|:|.|..:..|.:|..:...|..|..||:|.:..|::.:|:.|
Mosquito   459 VHTGEKPYTCDICSKGFAQKANLLSHRKTHLKPNVTYSCDRCARTFRSQKVLQMHVPKCTGGAGP 523

  Fly   494 ----------------------------------------------------------------- 493

Mosquito   524 IEGASVPPSAPVTPVSESIPDSPSPGAGVSLTTTSSSAVEAAANSTPPTLSEALSDLLRYEIALR 588

  Fly   494 -----QELM--HSDK-------------------------------------------------- 501
                 |:::  |.|:
Mosquito   589 APLELQQMLLGHIDRKGKPAQAGPGGKAAGRRYRCDVCFKGYSQYPSLIKHRKLHFKVPPLVKVL 653

  Fly   502 -------------------------------------------------PRPEPELQ-------- 509
                                                             |.|.|..|
Mosquito   654 AGKAGHHHQQDYEDGEMEEPSDGLVQPTGELHCRGVGGIGDAPPQPSPLPLPPPHHQPTGEPIER 718

  Fly   510 --QCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHI-YHNHECERKFKCT 571
              .|.|||...|....||.|.| :||. |...:|..|......|..||||: .|.....|.|.|.
Mosquito   719 PYSCDICGKTFKYNRNLKVHAK-LHVR-ANRFKCDKCTTTFAQAEDLRRHLPTHPTAAGRSFSCD 781

  Fly   572 MCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            .|...|:..::||.|..:||||..|.|..||..|...:|:..| .|:|
Mosquito   782 YCANRFRSSEDLKRHRRSHTGERPYRCTRCPKAFTQQSNLRAH-ARIH 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	22/122 (18%)
		C2H2 Zn finger	330..351	CDD:275368	8/22 (36%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	27/75 (36%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/102 (7%)
		C2H2 Zn finger	511..532	CDD:275368	9/20 (45%)
		C2H2 Zn finger	541..562	CDD:275368	8/21 (38%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
AgaP_AGAP011759	XP_320751.4	zf-AD	24..98	CDD:214871	15/67 (22%)
		C2H2 Zn finger	243..263	CDD:275368	4/23 (17%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		C2H2 Zn finger	326..346	CDD:275368	2/19 (11%)
		zf-H2C2_2	339..363	CDD:290200	7/26 (27%)
		COG5048	<351..513	CDD:227381	56/168 (33%)
		C2H2 Zn finger	354..374	CDD:275368	8/22 (36%)
		zf-H2C2_2	366..390	CDD:290200	8/23 (35%)
		C2H2 Zn finger	382..398	CDD:275368	4/15 (27%)
		C2H2 Zn finger	409..429	CDD:275368	9/19 (47%)
		C2H2 Zn finger	440..460	CDD:275368	7/22 (32%)
		zf-H2C2_2	452..477	CDD:290200	9/25 (36%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..514	CDD:275368	5/16 (31%)
		C2H2 Zn finger	623..643	CDD:275368	0/19 (0%)
		C2H2 Zn finger	722..742	CDD:275368	9/20 (45%)
		C2H2 Zn finger	750..770	CDD:275368	7/19 (37%)
		C2H2 Zn finger	780..800	CDD:275368	6/19 (32%)
		zf-H2C2_2	792..817	CDD:290200	12/24 (50%)
		C2H2 Zn finger	808..828	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910