DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP009068

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_319817.4	Gene:	AgaP_AGAP009068 / 1280023	VectorBaseID:	AGAP009068	Length:	619	Species:	Anopheles gambiae

Alignment Length:	688	Identity:	156/688 - (22%)
Similarity:	235/688 - (34%)	Gaps:	174/688 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCM--CEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKES--DERICGRCWKIVSDFHT 67
            |.:||  ||     .|.:.|:....|.| ::.::.:...|:|.|..  ....|..|
Mosquito    14 CRICMESCE-----DDCVCVYDEFEDVL-LSDVIRECARVEIRKNDALPRNACRNC--------- 63

  Fly    68 LHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIE 132
             .|::..|...:|:.:     |..:|..:. |...:.|..:|.:..|.           ..:.:.
Mosquito    64 -AEYLIIAYHIIQKCR-----DSDVTLRSI-FKHELNLHREERKPNTS-----------SVVGLR 110

  Fly   133 EHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKK 197
            ..::|......:|....:|.    .|||....|.   .|:...:...|:..|.|:| .|.|...:
Mosquito   111 ADDMDPSGYEFLLANGYDTM----MLEGEGMLLE---NADCDFTAPSDEKADSVQE-EEKALAAR 167

  Fly   198 RRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSC-----------LVPSDNSSE 251
            |                        |...|......|.|:.|.||           |..|:.|..
Mosquito   168 R------------------------LVTGETVHESSETTEEDGSCNEQKKCCGCRKLFSSEQSLR 208

  Fly   252 ----------DDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELL 306
                      :...|||..|:|.             |.|..|..|::.            ||:||
Mosquito   209 EHCQTVHLPVESSASDGPASESK-------------PIRCPVCFKRFS------------SRQLL 248

  Fly   307 EQRKKQQEEYDVII---AKFFT--------------SVLPCAIC--------NLLVHNFTEMQRH 346
            ::.::......|..   .:|.|              ....|..|        :||||:    |..
Mosquito   249 KEHERSVNRKYVCAQCGKRFMTQANLDTHTKCHKNKETYKCCGCRMDFEQELDLLVHS----QNV 309

  Fly   347 HRLTHQVDPGY-MMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLE-SHQQVHM 407
            |||...|||.. ..|  |.|::..||.||.|   ......|:|.:|...|.....|: .|::.|.
Mosquito   310 HRLERSVDPDKPFECDTCYRRYPTRKSLATH---KRQIRQFQCPLCGAMFMKQLFLQLHHERAHQ 371

  Fly   408 DPA-VKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEF---------KFTCSECNKKFLTERKLK 462
            ..| .|....|..|.:.|.:..|:..|....|.|....         .|.|:.|.|:|.:...|.
Mosquito   372 QEAQEKRRRCCGGCREVFENAAALRAHSERVHKPADGSAGSGTDDGKPFECNVCRKRFASIFFLL 436

  Fly   463 NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            .|...: ..|....|..||:.......|..|:....::.|      .:|.:|....|....||.|
Mosquito   437 QHQQKV-AREKCYPCTVCGRTFGRAHDLSNHETTHSNEMP------FECSVCSRRFKNKLYLKNH 494

  Fly   528 MKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTG 592
            :| :|..||.|..|..|.|.......|:.|:. :|...||:.||:|...|||.|.||.||..||.
Mosquito   495 LK-LHASSAKEQVCVECGKAFRTKDLLKTHLI-SHSQVRKYACTVCPATFKRLQCLKIHTRVHTR 557

  Fly   593 EVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQP 630
            |..:.|..|...:..|:::.:| .|.|.   ..|:.:|
Mosquito   558 EKAFECAVCRKRYVQSSDLKRH-MRTHN---PGDEGKP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	16/77 (21%)
		FYDLN_acid	<191..268	CDD:302856	18/97 (19%)
		C2H2 Zn finger	330..351	CDD:275368	10/28 (36%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	5/20 (25%)
		zf-C2H2_8	389..465	CDD:292531	20/86 (23%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	11/19 (58%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
AgaP_AGAP009068	XP_319817.4	zf-AD	13..86	CDD:214871	19/92 (21%)
		COG5048	<150..400	CDD:227381	68/306 (22%)
		C2H2 Zn finger	194..215	CDD:275368	3/20 (15%)
		C2H2 Zn finger	235..253	CDD:275368	6/29 (21%)
		C2H2 Zn finger	261..281	CDD:275368	2/19 (11%)
		C2H2 Zn finger	289..310	CDD:275368	7/24 (29%)
		C2H2 Zn finger	324..342	CDD:275368	8/20 (40%)
		C2H2 Zn finger	349..370	CDD:275368	5/20 (25%)
		C2H2 Zn finger	382..403	CDD:275368	5/20 (25%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		C2H2 Zn finger	450..470	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	507..527	CDD:275368	5/20 (25%)
		C2H2 Zn finger	535..555	CDD:275368	11/19 (58%)
		C2H2 Zn finger	563..583	CDD:275368	5/20 (25%)
		C2H2 Zn finger	594..612	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910