DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP009010

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_319758.4	Gene:	AgaP_AGAP009010 / 1279969	VectorBaseID:	AGAP009010	Length:	433	Species:	Anopheles gambiae

Alignment Length:	616	Identity:	130/616 - (21%)
Similarity:	210/616 - (34%)	Gaps:	206/616 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QHFPVQI--SKESDERICGRCWKIVSDF-------HTLHEFVSAAQSSLQETKVALMEDDPLTQE 95
            :||.:|:  .|.:...||..|...|:..       |..::..:.....|.:      |..||..:
Mosquito     1 KHFSLQLIEIKGTAANICEECLGFVNKLEHFEARCHQTNQLFTYLAKHLPD------ETHPLDLK 59

  Fly    96 ---TTSFPEIIKLATQEE--EGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQ 155
               :....|::.....||  |.:....||...|   .|:..:...|........||.:||..|..
Mosquito    60 QIRSKYLDEMLPNDGDEELFEVLEAESELADDN---TEVLYQVESLTVSSVQNELENNANETEQW 121

  Fly   156 DQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQ 220
            :.||                 ||.|...:|:|...|
Mosquito   122 EMLE-----------------VDMDDCSNGLETNDE----------------------------- 140

  Fly   221 LDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRP 285
             :::.||.|:|.|.:.:|:.|   .|.:.::.|.|....||:|..:.|:
Mosquito   141 -NVEEEEFDKFSDSDYEPETS---GSASGTKRDEGKGKDDSESPIDGDD---------------- 185

  Fly   286 KKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLT 350
                 .:.||               ||.::
Mosquito   186 -----ESVPA---------------KQPQK----------------------------------- 195

  Fly   351 HQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTF 415
                        |::|..:..:.:..||      :|..|.|:|:.:..|..|:.:|:....|..:
Mosquito   196 ------------RRYTTTRGASPNQQVH------QCKYCRKTFKCNSQLTRHEYIHLTQDGKPGY 242

  Fly   416 SCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKC 480
            ||::|.|.| :|::|                              .:.||..||:.....:|::|
Mosquito   243 SCEICRKVF-TKSSI------------------------------RRAHMRMMHEGAKPYMCEEC 276

  Fly   481 GKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICA 545
            ||...:|..||:|. ::||:: ||    .:|..|....|....||.| :..|.::.  :.|..|.
Mosquito   277 GKPFSSKGALKEHY-IVHSEE-RP----FKCAYCPKSFKNAPRLKTH-EDTHNDTL--YVCPHCG 332

  Fly   546 KVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSAN 610
            ......|.|..|:. .|..::||||..|...:||.:.||.|...|||...|.||.|..||...:|
Mosquito   333 LKLNTKRTLNMHMV-VHSDQKKFKCQECGNEYKRSKALKAHLILHTGLRPYQCPFCDKTFANGSN 396

  Fly   611 MYKHRQRLH---RAQYEADKNQPKPPNILKI 638
            ...|:::.|   .|..||...|....||.|:
Mosquito   397 CRSHKKKFHPRELAALEAAGGQKPAANIPKL 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	10/49 (20%)
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	0/20 (0%)
		C2H2 Zn finger	360..378	CDD:275368	2/17 (12%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	14/75 (19%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	0/16 (0%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
AgaP_AGAP009010	XP_319758.4	ASF1_hist_chap	<72..192	CDD:304562	37/208 (18%)
		COG5048	<171..402	CDD:227381	78/360 (22%)
		C2H2 Zn finger	213..233	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..265	CDD:275368	8/51 (16%)
		C2H2 Zn finger	273..293	CDD:275368	8/20 (40%)
		zf-H2C2_2	285..310	CDD:290200	9/30 (30%)
		C2H2 Zn finger	301..321	CDD:275368	6/20 (30%)
		C2H2 Zn finger	328..348	CDD:275368	5/20 (25%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		zf-H2C2_2	368..393	CDD:290200	12/24 (50%)
		C2H2 Zn finger	384..402	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910