DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP008515

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_316925.4	Gene:	AgaP_AGAP008515 / 1277455	VectorBaseID:	AGAP008515	Length:	640	Species:	Anopheles gambiae

Alignment Length:	746	Identity:	133/746 - (17%)
Similarity:	217/746 - (29%)	Gaps:	295/746 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLC-------MCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCW-KIVS 63
            |.:|       .|.:|....|.:|....|..||.          :||.....:.|||.|: |:.|
Mosquito    11 CRICGMDILDLTCAFPIFGNDRVDQKLERYLQLN----------IQIDDLLPKCICGSCYLKLES 65

  Fly    64 DFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEE----------GVTEPQE 118
                :.:|             |||                  |::.||          |:..|.|
Mosquito    66 ----IDQF-------------ALM------------------ASRTEEAFRAWLGRLRGLNSPAE 95

  Fly   119 LGGR-NFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKD 182
            .... |...|..:::.                         :|.|..     |....:|..||..
Mosquito    96 AAKNVNVMLPLFRLDP-------------------------DGGADS-----KKGHNASAAKDAR 130

  Fly   183 EDGVEETAEPAPPKKRRGRPRKSDAAVAPPQK---PKEDIQLDL--KAEELDEFV-------DEE 235
            .:.....:...||           |:|:||:|   ...|::|.|  |.:||.:.:       :.:
Mosquito   131 SNPSPTVSTATPP-----------ASVSPPEKGIISYSDLKLGLLIKDQELLKLILKALRWAEND 184

  Fly   236 TDPDFSCLVP--SDNSSEDDGGSDGFDSDSDFE------LDNG-KQEFAVLPKRTVVRPKKYKKR 291
            ....|..|:.  .::|..:...:....:|||..      :..| ...||.:|......|......
Mosquito   185 RRASFEVLIQRLKNSSFREILSNRNLLNDSDLTQLLKSYIGQGVMNSFAAMPPSAASTPLNNNNV 249

  Fly   292 TKPA---EPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQ- 352
            ..||   :|.:..:..:....:          :.|...|.|.|..|:..:...|..    :|..
Mosquito   250 VPPAVMFQPPINPTGGVKSGNQ----------SGFVAPVGPIAGVNVNEYRIDEAS----VTQME 300

  Fly   353 --VDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQ----------- 404
              |||...:                     |...:.|.....|:.:| :|..|:
Mosquito   301 VGVDPDLYL---------------------PYEDEDSSSTNKFEGTR-IEDRQENTVTIKLVTTN 343

  Fly   405 --------VHMDPAV-----KLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL 456
                    ..|.||:     ...|.|..|.:.|.:...:..|.:.:|:|::. :...:|..|..:
Mosquito   344 VAGDMIENKRMIPAILNVRGTKRFQCSACPECFETNGELQQHIVRRHLPRTN-RTVITEQGKPAI 407

  Fly   457 TERKLKNH------------------------MSSMHDPEST--------IICDKCGKQMRTK-- 487
            ..|..||.                        .|...:|.|.        ::..|..::...|
Mosquito   408 KIRVRKNKPIAGPLLPPKLIPPSAPVTLTATTPSPTKEPSSAPASPAKGELLVRKSKRKTSLKPE 472

  Fly   488 ---IILKKHQELMHSDK----------------------PRPEPELQQ-----CQICGAWLKGMT 522
               :||:|.|:.....|                      |.|:|:..:     |.:|...|....
Mosquito   473 VSSLILEKQQKKRKVQKGVQKPVQKEAQTPAPPPAPPAPPSPKPKTSRKSNAFCALCRKRLTPKQ 537

  Fly   523 GLKQHMKSIHVESAGEHRCHICAKVSPNARALRRH-IYH-------------------------- 560
            .::.||:..|    ..:.|..|.:...:|..|.|| .||
Mosquito   538 TMRVHMQQEH----SRYECEKCDRAFKSALNLSRHQQYHASSSSSSSSTSTVPTELVSSSVSTKR 598

  Fly   561 -------NHECERKFKCTMCEKAFKRPQELK 584
                   ..|.|:..||:.|||||||...||
Mosquito   599 AQKAAQQEEEKEQTHKCSYCEKAFKRSHHLK 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	18/81 (22%)
		FYDLN_acid	<191..268	CDD:302856	19/96 (20%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	0/17 (0%)
		LIM	361..>400	CDD:295319	4/38 (11%)
		C2H2 Zn finger	386..406	CDD:275368	5/38 (13%)
		zf-C2H2_8	389..465	CDD:292531	19/123 (15%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	5/40 (13%)
		C2H2 Zn finger	477..498	CDD:275368	6/25 (24%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	8/54 (15%)
		C2H2 Zn finger	570..590	CDD:275368	10/15 (67%)
		C2H2 Zn finger	598..619	CDD:275368
AgaP_AGAP008515	XP_316925.4	zf-AD	11..82	CDD:214871	24/115 (21%)
		C2H2 Zn finger	369..390	CDD:275368	4/20 (20%)
		C2H2 Zn finger	526..547	CDD:275368	5/20 (25%)
		zf-C2H2	550..572	CDD:278523	6/21 (29%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100