DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP006592

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_316619.4	Gene:	AgaP_AGAP006592 / 1277175	VectorBaseID:	AGAP006592	Length:	1029	Species:	Anopheles gambiae

Alignment Length:	360	Identity:	75/360 - (20%)
Similarity:	131/360 - (36%)	Gaps:	100/360 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PAEPKVRMSRELLEQRKKQ--QEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVD-P 355
            |..|..|..|.|....:|:  :..|:            |.:|:......:.::.|.| ||..: |
Mosquito   704 PGSPNSRGYRSLPYPLRKRDGKMHYE------------CNVCSKTFGQLSNLKVHLR-THSGERP 755

  Fly   356 GYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLC 420
            .....|.:.|||...|.:|.|||......:|.:|:|.|.::.:|::|.::|   :.:..::||||
Mosquito   756 FKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLH---SGQKPYACDLC 817

  Fly   421 SKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMR 485
            .:.|   |...:.||:|.:..::..:.|..|:||:::...|:.|.       .|..|.....:..
Mosquito   818 PQKF---TQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHW-------KTTSCKPNNLEEE 872

  Fly   486 TKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPN 550
            ..:......|.:..| .:|:.|               |.::..:..|..|.|.      ..|...
Mosquito   873 LAMAAAATSECLDKD-GQPDGE---------------GGREFYEMSHHGSPGG------VVVQQT 915

  Fly   551 ARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTG--EVLYTCPNCPMTFFCSANMYK 613
            |.||....:|.|.                     :|...|.|  :|::           ..:..|
Mosquito   916 AAALSPASHHQHH---------------------QHAGHHHGTEQVIH-----------KVSAGK 948

  Fly   614 HRQRLHRAQYEADKNQPKPPNILKISRNASTQNKP 648
            .:|:.|:.        |.||       |:|..|.|
Mosquito   949 IQQQQHQG--------PSPP-------NSSNNNSP 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	2/20 (10%)
		C2H2 Zn finger	511..532	CDD:275368	1/20 (5%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	1/19 (5%)
		C2H2 Zn finger	598..619	CDD:275368	2/20 (10%)
AgaP_AGAP006592	XP_316619.4	SET	74..177	CDD:214614
		Forkhead_N	606..725	CDD:254796	6/20 (30%)
		zf-C2H2	728..750	CDD:278523	5/34 (15%)
		C2H2 Zn finger	730..750	CDD:275368	4/20 (20%)
		zf-H2C2_2	742..767	CDD:290200	7/25 (28%)
		C2H2 Zn finger	758..778	CDD:275368	7/19 (37%)
		zf-H2C2_2	770..795	CDD:290200	9/24 (38%)
		C2H2 Zn finger	786..806	CDD:275368	6/19 (32%)
		zf-H2C2_2	798..823	CDD:290200	8/30 (27%)
		C2H2 Zn finger	814..834	CDD:275368	9/22 (41%)
		C2H2 Zn finger	842..861	CDD:275368	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910