DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP005484

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_315488.2	Gene:	AgaP_AGAP005484 / 1276175	VectorBaseID:	AGAP005484	Length:	484	Species:	Anopheles gambiae

Alignment Length:	644	Identity:	155/644 - (24%)
Similarity:	254/644 - (39%)	Gaps:	209/644 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQH-----------FPVQISKESDERI 54
            ||.  .|.||:               ||.:.|.....:.:.           ||:...:.....:
Mosquito     1 MDE--KCRLCL---------------ARLENLRSNATIEEEGFREKLKTLFSFPITSIEAFPSTV 48

  Fly    55 CGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQEL 119
            |.:|...||||||.||.|.:.|..|                         .:||.::
Mosquito    49 CVQCEARVSDFHTYHEQVKSNQDQL-------------------------WSTQHQK-------- 80

  Fly   120 GGRNFFYPEIKIE-----EHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDK 179
                 ::.::|:|     ::::..||.:|:           ..:|||.:...|..:..|..::|.
Mosquito    81 -----YFEKVKVEPAPDADYDVFELPFVEV-----------KPVEGAPKESCKNDEQLDVLAIDS 129

  Fly   180 DKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLV 244
            |.| ||::...|..||        .|.||
Mosquito   130 DLD-DGMKLEDEYNPP--------SSSAA------------------------------------ 149

  Fly   245 PSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAE----------PKV 299
             |:|:|:          ||::|                |:|::.|:.|..|:          ||.
Mosquito   150 -SNNNSD----------DSEYE----------------VKPRRSKRVTDTADRTRTTRRGRSPKS 187

  Fly   300 RM-SRELLEQRKKQ--------------QEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRL 349
            .. :|...||:||.              :|.||          :.|.:|...:.:|..:::|:..
Mosquito   188 EAGTRSPGEQKKKSPIVVRRGQATNQKLREFYD----------MKCEMCEEQLESFNALKKHYYQ 242

  Fly   350 THQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQ-QVHMDPAVKL 413
            ||:. .||:.||||.|.::..|.||:..|......:|..|.|:|.:..:|..|: :||..|..:
Mosquito   243 THRT-RGYIKCCGRTFHKQYRLLEHLSYHVGSSMVRCEECNKTFSSRSYLLVHRSRVHGQPEDR- 305

  Fly   414 TFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICD 478
            .:.|..|.:::    |::.| |..|: .|..:..|:.|.|:..:...|:.||.:||......|||
Mosquito   306 PYKCTQCHQSY----ALECH-LKAHI-VSHVRVNCTICGKELASAHSLRTHMINMHGNRENHICD 364

  Fly   479 KCGKQMRTKIILKKHQEL---MHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHR 540
            .||::.|::...::|.:|   :...|.      .||::|..||.....||.|::.:|:|:....:
Mosquito   365 TCGREFRSRPAFERHVKLHLGLEVTKQ------MQCEVCHKWLNSKRALKVHLQLVHMEAGQTFQ 423

  Fly   541 CHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST-HTGEVLYTC 598
            |.||::..||:|||..|....| .|.:|||..|.|.|||...||||.:. ||.:.||:|
Mosquito   424 CDICSQQYPNSRALANHKQFVH-VEERFKCEECGKLFKRQLYLKEHVAALHTRKPLYSC 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	21/84 (25%)
		FYDLN_acid	<191..268	CDD:302856	12/76 (16%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	8/17 (47%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/20 (30%)
		zf-C2H2_8	389..465	CDD:292531	19/76 (25%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/23 (30%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	10/20 (50%)
		C2H2 Zn finger	598..619	CDD:275368	1/1 (100%)
AgaP_AGAP005484	XP_315488.2	zf-AD	5..73	CDD:214871	20/82 (24%)
		C2H2 Zn finger	223..244	CDD:275368	4/20 (20%)
		C2H2 Zn finger	251..270	CDD:275370	8/18 (44%)
		C2H2 Zn finger	278..299	CDD:275368	6/20 (30%)
		C2H2 Zn finger	309..329	CDD:275368	6/25 (24%)
		C2H2 Zn finger	334..351	CDD:275368	4/16 (25%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..411	CDD:275368	6/16 (38%)
		C2H2 Zn finger	424..445	CDD:275368	9/20 (45%)
		C2H2 Zn finger	452..469	CDD:275368	9/16 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870