DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP005479

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_315481.3	Gene:	AgaP_AGAP005479 / 1276170	VectorBaseID:	AGAP005479	Length:	485	Species:	Anopheles gambiae

Alignment Length:	630	Identity:	159/630 - (25%)
Similarity:	240/630 - (38%)	Gaps:	163/630 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTL 68
            |..|.||:... :..|..|.:..|. .|.|:.|:.  ||.:.:.....|.:|..|...||..|:.
Mosquito     2 SEKCRLCLGSL-SSTGPKISIRDAE-FQEELKTVF--HFDIILDTALPEHVCNECRSTVSYCHSY 62

  Fly    69 HEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEE 133
            ...|.|.|                          .:|..:..|.|.:|.|    |.....:..|:
Mosquito    63 CLQVQANQ--------------------------FQLLGEANENVLKPVE----NVMVESLVEED 97

  Fly   134 HELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKD----KDEDGVEETAEPAP 194
            ....|...::..|.:.|.:...            .|:..:|.|||:|    |::
Mosquito    98 DCTKTEKHLQKEELAVNQEATM------------CLEDREGLSVDEDCVRGKND----------- 139

  Fly   195 PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGF 259
              |:|.|.|:|       .|.|.|:|             :||:       ..|.||:
Mosquito   140 --KQRRRARQS-------IKNKPDLQ-------------KETE-------NQDTSSK-------- 167

  Fly   260 DSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFF 324
                                                           |..:..|.|.|.||.:||
Mosquito   168 -----------------------------------------------EVSQANQLENDKIITQFF 185

  Fly   325 TSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
            |  |.|.||.....:|.::..|:|..|:. .||:.|||::|.:|.:|.:|:..|...  .:|.:|
Mosquito   186 T--LECEICAATAESFVQLLDHYRTAHKT-KGYVRCCGKQFFRRYILVDHIAAHRGT--IRCEIC 245

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKK 454
            .|:::..|:|..|............|.|..|..::..:..:..|:| .||.:.     |..|.|.
Mosquito   246 HKTYKTKRYLALHFAKSHSGETDRPFKCGKCHVSYPKQYLLRAHEL-MHVQQQ-----CHVCEKV 304

  Fly   455 FLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH-QELMHSDKPRPEPELQQCQICGAWL 518
            ....:.|:.|::.||..:...|||.|||..|||..:::| .|.|..|    ..|..||..|..|.
Mosquito   305 LSNTQSLRVHIAQMHGGDGHHICDTCGKVFRTKPAMERHINEHMGVD----VVERLQCDHCQKWF 365

  Fly   519 KGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQEL 583
            .|...|::|::.:|:|......|.:|...|||:|||..|....| .|.:|:|..|.|.|||...|
Mosquito   366 SGKYNLRKHVRFMHLEGGQVFWCELCPHESPNSRALANHKLRVH-VEERFECEYCGKRFKRRPNL 429

  Fly   584 KEHTSTHTGEVLYTCPNCP-MTFFCSANMYKHRQRLHRAQYEADK 627
            :||.::||...||:|..|. .||...||.:.||:..|..::||.|
Mosquito   430 REHIASHTNMPLYSCEICQNRTFNSKANYFTHRKHKHPQEWEAQK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	20/73 (27%)
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	16/75 (21%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	10/21 (48%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	8/21 (38%)
AgaP_AGAP005479	XP_315481.3	zf-AD	5..74	CDD:285071	20/98 (20%)
		C2H2 Zn finger	219..236	CDD:275368	6/16 (38%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	273..293	CDD:275368	4/20 (20%)
		C2H2 Zn finger	298..319	CDD:275368	5/20 (25%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		C2H2 Zn finger	358..374	CDD:275368	5/15 (33%)
		C2H2 Zn finger	388..409	CDD:275368	9/20 (45%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	444..463	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870