DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP005348

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_315360.4	Gene:	AgaP_AGAP005348 / 1276055	VectorBaseID:	AGAP005348	Length:	397	Species:	Anopheles gambiae

Alignment Length:	625	Identity:	127/625 - (20%)
Similarity:	208/625 - (33%)	Gaps:	264/625 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSARGDQLE--VTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLH 69
            ||||:...        :..::...:||  |.:::.:||.........:.:|..||..|.:|:|
Mosquito    13 CLLCLSSQ--------EHANSLCSELEPKVVSVLCRHFWFTAEDIQQKYVCSACWAQVDEFNT-- 67

  Fly    70 EFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEH 134
                                                                   ||
Mosquito    68 -------------------------------------------------------FY-------- 69

  Fly   135 ELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRR 199
                    |::||..:.:| |:|              .|||.:             ||.|
Mosquito    70 --------ELVERIHHAEE-QNQ--------------HDGSKL-------------EPLP----- 93

  Fly   200 GRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSD--NSSEDDGGSDGFDSD 262
                 ::.:.|..:.|:.|        |:.|.:.:::|.:...:..|:  |..|..|.|..|
Mosquito    94 -----TEDSCAYAESPETD--------EIHESIPDDSDSETVLIETSEELNLEEVSGESVVF--- 142

  Fly   263 SDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSV 327
                              |:.|..|                    :..:|.:|.:.
Mosquito   143 ------------------TIERNTK--------------------ESPQQSDEIET--------- 160

  Fly   328 LPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKS 392
                                              |..| ...:..||
Mosquito   161 ----------------------------------GPNF-DNVIEFEH------------------ 172

  Fly   393 FQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLT 457
                 |.||.......|.|..::.||.|.:.:..:     |.||:|              :|:|:
Mosquito   173 -----HEESEDATQNGPEVAESYKCDQCDRVYPKR-----HLLNRH--------------RKYLS 213

  Fly   458 ERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMT 522
            |.:|:.|...:|.|  ..:||.|.|..:|...|::||:..|:..   |.|..:|.||..|||...
Mosquito   214 ETRLQQHKKRVHGP--GFMCDACPKWYKTGEALRRHQKDSHNPY---ETERVECHICKRWLKNKG 273

  Fly   523 GLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHT 587
            .|::|:.. |..|..::.|.||.||:|...||:.|....|:.::.::|.:|.|||||...|:||.
Mosquito   274 SLRKHLNR-HKTSGMQNVCEICGKVAPTHTALKSHKLFVHKMQKSYQCNVCYKAFKRAFTLEEHM 337

  Fly   588 STHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADK 627
            :.|||..||.||:||.||..|||::.|:::.|..::|..:
Mosquito   338 TIHTGSTLYKCPHCPKTFNSSANLHGHKKKAHPKEWERSR 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/75 (20%)
		FYDLN_acid	<191..268	CDD:302856	15/78 (19%)
		C2H2 Zn finger	330..351	CDD:275368	0/20 (0%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	5/38 (13%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	16/75 (21%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	10/19 (53%)
		C2H2 Zn finger	598..619	CDD:275368	10/20 (50%)
AgaP_AGAP005348	XP_315360.4	zf-AD	13..76	CDD:214871	20/143 (14%)
		C2H2 Zn finger	192..225	CDD:275368	12/51 (24%)
		C2H2 Zn finger	231..252	CDD:275368	8/20 (40%)
		C2H2 Zn finger	262..282	CDD:275368	8/20 (40%)
		C2H2 Zn finger	291..312	CDD:275368	9/20 (45%)
		C2H2 Zn finger	320..340	CDD:275368	10/19 (53%)
		C2H2 Zn finger	348..366	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24403
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010