DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP004575

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_313884.5	Gene:	AgaP_AGAP004575 / 1274718	VectorBaseID:	AGAP004575	Length:	479	Species:	Anopheles gambiae

Alignment Length:	596	Identity:	136/596 - (22%)
Similarity:	231/596 - (38%)	Gaps:	160/596 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEP 116
            :::|.||...|.::::.::.|..||..||                          |::|
Mosquito     3 DKVCDRCVTKVHEYYSFYQQVIRAQQLLQ--------------------------TEKE------ 35

  Fly   117 QELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDK 181
                                                          |.:|.|:||:....:..|:
Mosquito    36 ----------------------------------------------RVIRNRVKADSIHLIASDE 54

  Fly   182 DEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELD----EFVDEETDPDFSC 242
            ..|               .:....|.|:    :..:...:.||....|    ::||.:...:...
Mosquito    55 AND---------------SKHYNHDEAI----ETHDTKNILLKNGATDYVSTDYVDRKPAEEKIS 100

  Fly   243 LVPSDNSSED-------DGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVR 300
            ::.::|..::       ||..:.|::.|...:                   |||.
Mosquito   101 IITTNNEHDEQSQEIKVDGKIESFEAKSQSNI-------------------KYKS---------- 136

  Fly   301 MSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKF 365
            .:.:.....|||.|:.| .|.:||:.|  |.||:.....|..:|.|.|..|.: .|:::||.:||
Mosquito   137 TANDKKNAFKKQIEDND-RIREFFSIV--CEICSKEFSTFQRLQTHSRKAHHI-RGFIVCCNQKF 197

  Fly   366 TQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAI 430
            .:...:.:|:..|..||.|:|.:|||::::...|:.|.:.|.....:..|.|:.|.::|.....:
Mosquito   198 FRTFRVLDHIAFHLKPDAFRCELCEKNYRSRYTLQEHNKSHHAEPKERPFKCNQCHQSFFRTFRV 262

  Fly   431 DYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH-- 493
            ..| :..|:....|:  |..|.|.:.|...|:.|..:.|......|||.||.|.||:..|::|
Mosquito   263 LDH-IAFHLKPDAFR--CELCEKNYRTRYTLQEHNKNHHAEPKRQICDTCGLQFRTRAALERHVR 324

  Fly   494 ----QELMHSDKPRPEPELQQCQICGAWLKGMTG-LKQHMKSIHVESAGEHRCHICAKVSPNARA 553
                ||        .|.|.:||..|..|:.|..| ||.|.:::|........|.||.:...||..
Mosquito   325 GRLGQE--------KENEKRQCPQCEVWVSGGAGVLKHHTQNLHPAKDKVFECDICQRRCKNATT 381

  Fly   554 LRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRL 618
            |.:|....| .:.:::...|.|.|||...||||.:.||.::||:|..|.:....:||||.|.:|.
Mosquito   382 LYQHRKGVH-AQDQYESEYCGKRFKRKIGLKEHRALHTEQMLYSCSECDLKTNSNANMYSHIKRK 445

  Fly   619 HRAQYEADKNQ 629
            |..:::..:.|
Mosquito   446 HPIEWQEAQKQ 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	8/28 (29%)
		FYDLN_acid	<191..268	CDD:302856	12/87 (14%)
		C2H2 Zn finger	330..351	CDD:275368	7/20 (35%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	18/75 (24%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	11/26 (42%)
		C2H2 Zn finger	511..532	CDD:275368	8/21 (38%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
AgaP_AGAP004575	XP_313884.5	zf-AD	<2..32	CDD:214871	9/54 (17%)
		C2H2 Zn finger	193..210	CDD:275368	4/16 (25%)
		C2H2 Zn finger	218..238	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	4/20 (20%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..324	CDD:275368	9/17 (53%)
		C2H2 Zn finger	369..390	CDD:275368	7/20 (35%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		C2H2 Zn finger	425..443	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870